International variation in child healthcare practices and implications for childhood cancer diagnosis: a scoping review and cross-country clinician survey

Autores de IIS La Fe

• Adela Cañete Nieto

  Autor

Participantes ajenos a IIS La Fe

• Lopez-Cortes A.
• Al-Mahdy A.
• Jakab Z.
• Shimato M.
• Botta L.
• Didonè F.
• Stiller C.A.
• Gatta G.
• Pritchard-Jones K.
• Klein M.
• Di Cataldo A.
• Capocaccia R.
• Greene G.
• Polanco A.
• Smits S.
• Huws D.W.
• Smith K.
• Morrison D.S.
• Bennett D.
• Fitzpatrick D.
• Gavin A.
• Irvine L.
• Stevens S.
• Karim-Kos H.
• Visser O.
• Redmond S.M.
• Kuehni C.E.
• Lähteenmäki P.
• Carulla M.
• Peris-Bonet R.
• Pardo E.
• Guevara M.
• Chirlaque M.D.
• Parra-Blazquez D.
• Aragones N.
• Sanchez M.J.
• Puigdemonte M.
• Jeghalef-ElKaroui N.
• Alemda-Vich F.
• López-de-Munain-Marqués A.
• Zadnik V.
• Coza D.
• Bucurenci M.
• Caldas G.
• Ferreira A.M.
• Raciborska A.
• Kowalczyk J.
• Zeller B.
• Dahlen A.H.
• Johannesen T.B.
• Azzopardi M.J.
• Nakata K.
• Matsuda T.
• Murray D.
• Guzzinati S.
• Zorzi M.
• Mantovani W.
• Scuderi T.
• Intrieri T.
• Caldarella A.
• Bella F.
• Pinna P.
• Piras D.
• Stracci F.
• Coccia P.
• Manasse S.
• Spata E.
• Falcini F.
• Ferretti S.
• Spagnoli G.
• Mangone L.
• Michiara M.L.
• Borciani E.
• Gambino M.L.
• Gervasi F.
• Russo A.G.
• Bruno D.
• Cuccaro F.
• Amodio R.
• Rognomi M.
• Boni L.
• Ragusa R.
• Torrisi A.
• Dal Maso L.
• Ballotari P.
• Sacerdote C.
• Maule M.M.
• Sessa M.
• Piga P.
• Sampietro G.
• Galasso R.
• Garami M.
• Bouka E.
• Petridou E.T.
• Spix C.
• Trübenbach C.
• Ressing M.
• Poulalhon C.
• Clavel J.
• Desandes E.
• Lacour B.
• Paapsi K.
• Falck Winther J.
• Hjalgrim L.L.
• Sterba J.
• Stary J.
• Pole J.D.
• Gupta S.
• Konstantinov D.
• Valerianova Z.
• Valentim Leite R.
• de Souza P.C.F.
• Pontes de Aquino A.
• Veneziano D.B.
• de Paulo R.N.
• Bastos Daniel C.
• Miranda C.S.M.
• Laporte C.A.
• Nativio J.
• Pena G.P.
• Casale C.A.
• Ferreira dos Santos L.
• Formigosa L.A.C.
• Ramos W.
• Lima C.A.
• De Oliveira Santos M.
• De Camargo B.
• Van Damme N.
• Van Eycken E.
• Ladenstein R.
• Hackl M.
• Youlden D.
• O’Neil L.
• Aitken J.

Grupos

• Investigación Clínica y Traslacional en Cáncer

Abstract

Childhood cancer survival and stage at diagnosis vary internationally. Here, we explore differences in child health surveillance and healthcare practices across countries participating in the International Benchmarking of Childhood Cancer Survival by Stage (BENCHISTA) collaboration—with a focus on timely cancer diagnosis. We conducted a scoping review of five databases (MEDLINE, Embase, SCOPUS, Web of Science, and ProQuest Central) for articles published in English or Spanish between 1 Jan 2012 and 15 Oct 2025, describing child health surveillance and acute care pathways, limited to the 29 countries involved in the BENCHISTA collaboration. Two reviewers independently screened abstracts; a third resolved conflicts. In parallel, a semi-structured questionnaire was distributed (to one general practitioner, one paediatrician) in 27 countries who contributed to the BENCHISTA database. We collected standardised information on national child health practices and validated against published national guidance. Of 2,963 articles screened, 33 were included. Three key themes emerged: (1) healthcare-seeking behaviour of families and their interaction with frontline professionals, (2) awareness of alarm symptoms by caregivers and clinicians, and (3) system-level and training-related factors affecting timely diagnosis. Studies highlighted challenges such as low symptom recognition, variation in paediatric training, and limited referral guidance. Questionnaire responses showed variation in the number of routine child health checks with physical examination for children < 5 years (median 10; range 2–21), paediatric training, and access to diagnostic tools. Conclusion: There is substantial international variation in routine child health surveillance and acute illness assessment. These findings will inform interpretation of BENCHISTA data and may guide future strategies to support early cancer diagnosis. (Table presented.) © The Author(s) 2026.

Keywords

• Child; Child Health Services; Early Detection of Cancer; Humans; Neoplasms; Practice Patterns, Physicians'; Surveys and Questionnaires; Article; benchmarking; cancer diagnosis; cancer registry; cancer survival; caregiver; child health; childhood cancer; consultation; diagnosis time; emergency ward; general practitioner; health care access; health care practice; help seeking behavior; human; patient referral; pediatrician; physical examination; questionnaire; scoping review; sociodemographics; structured questionnaire; child; child health care; clinical practice; diagnosis; early cancer diagnosis; neoplasm