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Outcomes of pediatric and adult patients with relapsed/refractory cortical (CD1a+) T-cell acute lymphoblastic leukemia. The Spanish experience from SEHOP and PETHEMA groups

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Rivera-Pérez C.
  • Morgades M.
  • Alonso-Saladrigues A.
  • Murciano T.
  • Gil C.
  • Adán R.
  • Esteve J.
  • Amigo M.L.
  • González-Martínez B.
  • Coll R.
  • Dapena J.L.
  • de Llano M.P.Q.
  • Fuster J.L.
  • García-Cadenas I.
  • Tasso M.
  • Barba P.
  • Rives S.
  • Ribera J.M.

Grupos

Abstract

Patients with relapsed/refractory T-cell acute lymphoblastic leukemia (R/R T-ALL) have very poor prognosis. CAR T-cell therapy is being explored in these patients with encouraging results. Specifically, CD1a-directed CAR T-cells are being explored in clinical trials to treat cortical T-ALL (CD1a+), but there are no data on outcome in this subgroup of patients before this therapy. This retrospective, observational study aimed to describe the characteristics and outcomes of patients with R/R CD1a + T-ALL. We included pediatric and adult patients diagnosed with R/R CD1a + T-ALL in 25 sites of Spain between March 2006 and May 2022. The primary outcome of the study was overall survival (OS). Forty-three patients, 28 adults and 15 children, with R/R CD1a + T-ALL were included. Median (range) age at inclusion was 24 years (5–57), and 82.5% were male. After a median (range) follow-up of 7.0 years (5.1–13.6), 6 (14.0%) patients were alive and in complete remission (CR) and 37 (86.0%) had died. Five-year OS was 16% (95% CI; 7–29%). Bone marrow relapse, an interval < 12 months between first CR and relapse, and lack of allogeneic hematopoietic stem cell transplantation during salvage treatment were associated with worse OS. Our results confirm that patients with R/R CD1a + T-ALL have a very poor prognosis, highlighting the need for new treatment alternatives in these patients. © The Author(s) 2026.

Datos de la publicación

ISSN/ISSNe:
0939-5555, 1432-0584

ANNALS OF HEMATOLOGY  SPRINGER

Tipo:
Article
Páginas:
-
PubMed:
41874722
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
0,994 SCImago ℠
Cuartil:
Q1 SCImago ℠

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Keywords

  • t6 antigen; adolescent; adult; article; child; drug therapy; female; human; major clinical study; male; side effect; T cell acute lymphoblastic leukemia; therapy

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