Portal de investigación
Symptom-guided approach to central nervous system complications in allogeneic hematopoietic cell transplant recipients: Best practice recommendations from the EBMT Practice Harmonisation and Guidelines committee
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Velasco R.
- Schmidt-Hieber M.
- Penack O.
- Averbuch D.
- Baccelli F.
- Bataller L.
- Cesaro S.
- Briani C.
- de la Cámara R.
- Huehnchen P.
- de Silva T.
- Mussetti A.
- Ljungman P.
- Peric Z.
- Mikulska M.
- Polushin A.
- Navarro Ortega D.
- Pons-Escoda A.
- Neofytos D.
- Schoemans H.
- Piñana J.L.
- Onida F.
- Ruggeri A.
- Sanchez-Ortega I.
- Yakoub-Agha I.
- Styczynski J.
Grupos
Abstract
Central nervous system complications (CNSC) after allogeneic hematopoietic cell transplantation (allo-HCT) are relatively common and may have a major impact on patients´ outcomes. Neurological symptoms may occur at any point during the post-transplant course, although they are more common early after HCT, with a wide range of possible presentations. As many of CNSC symptoms are non-specific, the initial assessment is often difficult, and early decisions regarding the diagnostic work-up can influence the identification of the underlying cause. Blood tests, neuroimaging and cerebrospinal fluid (CSF) analyses are particularly important, as they frequently provide the first clues that help narrow the very wide differential diagnoses. In view of these challenges, an international EBMT working group composed of haematologists, infectious disease specialists, neurologists, a neuroradiologist, and a microbiologist developed symptom-based recommendations for the early evaluation of CNSC after allo-HCT. The work summarizes key aspects of the clinical presentation and outlines practical steps for the initial diagnostic approach. These recommendations are intended to support haematologists, who are usually the first to assess these patients, in promptly recognizing CNSC so to start timely appropriate management. © The Author(s), under exclusive licence to Springer Nature Limited 2026.
Datos de la publicación
- ISSN/ISSNe:
- 0268-3369, 1476-5365
- Tipo:
- Review
- Páginas:
- -
- PubMed:
- 42098382
- Enlace a otro recurso:
- www.scopus.com
- Factor de Impacto:
- 0,998 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
BONE MARROW TRANSPLANTATION SPRINGERNATURE
Documentos
- No hay documentos
Filiaciones
Keywords
- adult; best practice; central nervous system complication; cerebrospinal fluid; clinical practice guideline; communicable disease; complication; diagnosis; differential diagnosis; drug therapy; female; graft recipient; hematologist; hematopoietic cell; human; infectious disease specialist; microbiologist; neuroimaging; neurologic disease; neurologist; neuroradiologist; practice guideline; review; symptom; therapy
Cita
Velasco R,Schmidt M,Penack O,Averbuch D,Balaguer A,Baccelli F,Bataller L,Cesaro S,Briani C,de la Cámara R,Huehnchen P,de Silva T,Mussetti A,Ljungman P,Peric Z,Mikulska M,Polushin A,Navarro D,Pons A,Neofytos D,Schoemans H,Piñana JL,Onida F,Ruggeri A,Sanchez I,Yakoub I,Styczynski J. Symptom-guided approach to central nervous system complications in allogeneic hematopoietic cell transplant recipients: Best practice recommendations from the EBMT Practice Harmonisation and Guidelines committee. Bone Marrow Transplant. 2026. 61(7):p. 805-815. IF:5,100. (1).