One-year follow-up of patients with severe tricuspid regurgitation: prognostic impact of right heart failure staging

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Gómez-Polo J.C.
  • Gómez-Salvador I.
  • Mahía Casado P.
  • Pérez David E.
  • Pericàs P.
  • Parada Barcia J.A.
  • Izurieta C.
  • Revilla Orodea A.
  • Moñivas V.
  • Testa A.
  • Miguel L.
  • Carrión-Sánchez I.
  • Gutiérrez L.
  • Ortega Trujillo J.R.
  • Hernández Vicente N.
  • Torres Quintero L.
  • Zaldua Irastorza O.
  • Delgado Ortega M.
  • Millán M.V.
  • Pérez M.L.Á.
  • Aguilera A.
  • Pascual I.
  • Méndez I.
  • Abuli Lluch M.
  • Romero Delgado T.
  • González Gómez A.
  • Del Castillo S.
  • Martín de la Fuente P.
  • Morillas P.
  • Gaitán D.
  • Mogollón M.V.
  • Payá Chaume A.
  • Bouzas A.
  • Pérez J.
  • Sánchez J.
  • López Cuenca Á.
  • Amao E.
  • Fernández Camacho J.C.
  • Blasco T.
  • Roldán I.
  • Graupner C.
  • Manzano C.
  • Martínez Monzonis A.
  • Ruiz Majoral A.
  • Vannini L.
  • Baquero M.
  • Rodríguez L.
  • Cabrera F.
  • Rollán M.J.
  • Reyes R.
  • Fernández Pérez C.
  • San Román J.A.
  • Vilacosta I.

Grupos

Abstract

INTRODUCTION: Severe tricuspid regurgitation (STR) is associated with adverse outcomes. This nationwide registry describes the prevalence, aetiology, clinical, and echocardiographic profile of STR using contemporary classifications, and evaluates the prognostic impact of a modified right heart failure staging (RHFS). METHODS: We prospectively enrolled consecutive patients with STR from 48 centres over 6 months and followed them for 1 year. TR severity (severe, massive, torrential) and aetiology were defined using current recommendations. A modified RHFS incorporating RV remodelling and systolic dysfunction was applied. RESULTS: We included 1247 patients (mean age 76.7 ± 10.5 years; 70.2% women): 64.9% had severe TR, 24.1% massive TR, and 11.0% torrential TR. V-STR due to left-heart disease was the most frequent aetiology (49.9%), followed by A-STR (19.8%). During follow-up, HF hospitalization occurred in 20.8%, cardiovascular death in 9.2%, and 12.3% underwent tricuspid intervention. In multivariable analysis, Stages III-IV of the modified RHFS were independently associated with HF hospitalization (HR 1.58; 95% CI 1.13-2.23; P = .008) and cardiovascular mortality (HR 2.01; 95% CI 1.27-3.18; P = .003). Massive (HR 1.72; 95% CI 1.02-2.91; P = .041) and torrential TR (HR 2.57; 95% CI 1.24-5.34; P = .011) were also associated with cardiovascular mortality. CONCLUSION: Massive and torrential TR identify patients at the highest risk. The modified RHFS stratifies patients with STR into prognostic categories and may help guide the timing of intervention. © The Author(s) 2026. Published by Oxford University Press on behalf of the European Society of Cardiology.

Datos de la publicación

ISSN/ISSNe:
2055-5822, 2055-5822

ESC Heart Failure  WILEY PERIODICALS, INC

Tipo:
Article
Páginas:
-
PubMed:
41711208
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
0,797 SCImago
Cuartil:
Q2 SCImago

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Keywords

  • biological marker; adverse outcome; article; atrial fibrillation; cardiovascular mortality; controlled study; echocardiography; female; follow up; heart disease; heart failure; heart right ventricle failure; hospitalization; human; major clinical study; male; prevalence; surgery; systolic dysfunction; tricuspid valve regurgitation

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