Validation of the Formulas for Mechanical Power in Children and Proposal of the Concept of “Effective Mechanical Power”

Autores de IIS La Fe

• Alicia Baza Del Amo

  Autor

• Yolanda Rubio Atienza

  Autor

• Marta Aguar Carrascosa

  Autor

• Vicent Modesto Alapont

  Autor

Participantes ajenos a IIS La Fe

• Ferrón-Vivó M.
• Rupérez M.J.
• Martínez-Millana A.
• Pedrosa A.M.
• Tornero-Costa R.
• Camilo C.
• Medina A.

Grupos

• Perinatología

Abstract

Background/Objectives: Recently, studies have emerged raising ergotrauma as a new explanation for ventilator-induced lung injury development, with the concept of inspiratory Mechanical Power (MP) as a single physical variable to estimate the contribution of different ventilatory parameters to lung damage. A high value of inspiratory MP is associated with risk of harming the respiratory system. Furthermore, we propose the concept of effective MP as the energy per minute that dissipates in the lungs, subtracting expiratory MP from inspiratory MP. Our objective is to validate the equations proposed for adults to estimate inspiratory MP in children, and to develop and validate equations to estimate effective MP. Methods: Prospective convenience sampling of 18 children undergoing mechanical ventilation in volume-controlled ventilation mode, admitted to the pediatric intensive care unit of a tertiary university hospital. Data of ventilation parameters, loops and curves were obtained electronically with the automated procedure provided by the device software and compared with the theoretical results of the equations. Results: Among the available equations for calculating inspiratory MP in adults under volume-controlled ventilation, the simplified Gattinoni and generalized Giosa equations provided the best estimates in children (R2 > 0.99). For expiratory MP, the extended equation proposed in this study showed the best agreement with experimental results (R2 = 0.9954). Finally, for effective MP, the simplified equation was the most accurate (R2 = 0.9950). Conclusions: This study validated existing inspiratory MP equations in pediatric patients and introduced the concept of effective MP, together with a bedside equation for its estimation. Future studies should determine effective MP thresholds associated with ventilator-induced injury. © 2026 by the authors.

Keywords

• airway resistance; Article; artificial ventilation; breathing mechanics; breathing rate; child; clinical article; controlled study; disease severity; expiratory flow; human; ideal body weight; lung capacity; lung injury; lung volume; peak inspiratory pressure; pediatric intensive care unit; positive end expiratory pressure ventilation; prospective study; respiratory distress syndrome; tidal volume; ventilator induced lung injury; volume controlled ventilation