Effect of beta blockers in acute and chronic coronary syndromes without reduced ejection fraction: a landmark analysis from the REBOOT trial

Autores de IIS La Fe

• Jaume Agüero Ramón-Llin

  Autor

Participantes ajenos a IIS La Fe

• Rossello, X
• Barrabés, JA
• Piepoli, M
• Dominguez-Rodriguez, A
• Sánchez, PL
• Anguita, M
• Raposeiras-Roubín, S
• Grigis, G
• Owen, R
• Pocock, S
• Pérez-García, CN
• Escalera, N
• Kallmeyer, A
• Sionis, A
• Staszewsky, L
• Torres, A
• Barquero, R
• Fernández-Vazquez, F
• Marín, F
• Vetrano, A
• Pastor, P
• Fuster, V
• Latini, R
• Ibanez, B

Grupos

• Grupo de Investigación Clínica y Traslacional en Cardiología

Abstract

Aims Current guidelines recommend beta-blocker therapy after myocardial infarction (MI) regardless of left ventricular ejection fraction (LVEF). However, recent trials question their benefit in patients with preserved LVEF. No study has yet compared beta-blocker effects during the acute coronary syndrome (ACS) phase (<= 1 year post-MI) vs. the chronic coronary syndrome (CCS) phase (>1 year). Methods and results In this pre-specified landmark analysis of the REBOOT trial, we evaluated the effect of beta-blocker therapy on outcomes in two post-MI phases: the ACS period (first year; cohort 1, n = 8438) and the CCS period (>1 year, event-free patients with follow-up; cohort 2, n = 7783). The primary endpoint was all-cause death, nonfatal reinfarction, or heart failure hospitalization; secondary endpoints included individual and additional cardiovascular events. Among 623 primary outcome events, 238 occurred in the first year (28.9/1000 patient-years) and 385 thereafter (19.3/1000 patient-years). Secondary prevention use was generally high, but patients with early events had lower prescription rates than those with late events or no events. Beta-blockers were not associated with lower risk of the primary or component outcomes in either phase. A nonsignificant trend towards benefit of beta-blockers appeared during the first year in patients with mildly reduced LVEF (41-49%), whereas in the CCS phase, higher beta-blocker doses were associated with worse outcomes. Conclusion In invasively treated MI patients with LVEF >40%, beta-blockers did not reduce adverse outcomes in either the ACS or CCS phases. These findings challenge their routine use in this population and support reconsidering current guidelines. Long-term beta-blocker users after MI may be candidates for deprescription.