Portal de investigación
SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- de Luca, G.
- Algowhary, M.
- Uguz, B.
- de Oliveira, D.C.
- Ganyukov, V.
- Zimbakov, Z.
- Cercek, M.
- Jensen, L.
- Loh, P.H.
- Câlmâc, L.
- Roura i Ferrer, G.
- de Quadros, A.
- Milewski, M.
- Scotto Di Uccio, F.
- von Birgelen, C.
- Versaci, F.
- Ten Berg, J.
- Casella, G.
- Wong Sung Lung, A.
- Kala, P.
- Carrillo-Suárez, X.
- Dirksen, M.
- Becerra-Muñoz, V.M.
- Kang-Yin Lee, M.
- Juzar, D.A.
- de Moura Joaquim, R.
- de Simone, C.
- Milicic, D.
- Davlouros, P.
- Bakraceski, N.
- Zilio, F.
- Donazzan, L.
- Kraaijeveld, A.
- Galasso, G.
- Arpad, L.
- Marinucci, L.
- Guiducci, V.
- Menichelli, M.
- Scoccia, A.
- Yamaç, A.H.
- Ugur Mert, K.
- Flores-Ríos, X.
- Kovárník, T.
- Kidawa, M.
- Moreu, J.
- Flavien, V.
- Fabris, E.
- Lozano Martínez-Luengas, I.
- Boccalatte, M.
- Bosa-Ojeda, F.
- Arellano Serrano, C.
- Caiazzo, G.
- Cirrincione, G.
- Kao, H.-L.
- Sanchís, J.
- Vignali, L.
- Pereira, H.
- Manzo-Silbermann, S.
- Ordonez, S.
- Arat-Özkan, A.
- Scheller, B.
- Lehtola, H.
- Teles, R.
- Mantis, C.
- Antti, Y.
- Brum Silveira, J.A.
- Bessonov, I.
- Zoni, R.
- Savonitto, S.
- Kochiadakis, G.
- Alexopoulos, D.
- Uribe, C.E.
- Kanakakis, J.
- Faurie, B.
- Gabrielli, G.
- Gutiérrez, A.
- Bachini, J.P.
- Rocha, A.
- Tam, F.C.-C.
- Rodriguez, A.
- Lukito, A.A.
- Bellemain-Appaix, A.
- Pessah, G.
- Cortese, G.
- Parodi, G.
- Burgadha, M.A.
- Kedhi, E.
- Lamelas, P.
- Suryapranata, H.
- Nardin, M.
- Verdoia, M.
Grupos
Abstract
SARS-Cov-2 has been suggested to promote thrombotic complications and higher mortality. The aim of the present study was to evaluate the impact of SARS-CoV-2 positivity on in-hospital outcome and 30-day mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) enrolled in the International Survey on Acute Coronary Syndromes ST-segment elevation Myocardial Infarction (ISACS-STEMI COVID-19 registry. The 109 SARS-CoV-2 positive patients were compared with 2005 SARS-CoV-2 negative patients. Positive patients were older (P =.002), less often active smokers (P =.002), and hypercholesterolemic (P =.006), they presented more often later than 12 h (P =.037), more often to the hub and were more often in cardiogenic shock (P =.02), or requiring rescue percutaneous coronary intervention after failed thrombolysis (P <.0001). Lower postprocedural Thrombolysis in Myocardial Infarction 3 flow (P =.029) and more thrombectomy (P =.046) were observed. SARS-CoV-2 was associated with a significantly higher in-hospital mortality (25.7 vs 7%, adjusted Odds Ratio (OR) [95% Confidence Interval] = 3.2 [1.71-5.99], P <.001) in-hospital definite in-stent thrombosis (6.4 vs 1.1%, adjusted Odds Ratio [95% CI] = 6.26 [2.41-16.25], P <.001) and 30-day mortality (34.4 vs 8.5%, adjusted Hazard Ratio [95% CI] = 2.16 [1.45-3.23], P <.001), confirming that SARS-CoV-2 positivity is associated with impaired reperfusion, with negative prognostic consequences. © The Author(s) 2022.
Datos de la publicación
- ISSN/ISSNe:
- 0003-3197, 1940-1574
- Tipo:
- Article
- Páginas:
- 987-996
- PubMed:
- 36222189
- Enlace a otro recurso:
- www.scopus.com
- Factor de Impacto:
- 0,640 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
ANGIOLOGY SAGE PUBLICATIONS INC
Citas Recibidas en Web of Science: 3
Citas Recibidas en Scopus: 4
Documentos
- No hay documentos
Filiaciones
Keywords
- bivalirudin; cangrelor; drug eluting stent; glycoprotein IIb; glycoprotein IIIa; acute coronary syndrome; aged; angiography; Article; bleeding; blood clot lysis; cardiogenic shock; coronavirus disease 2019; diabetes mellitus; dual antiplatelet therapy; female; heart failure; heart infarction; human; hypercholesterolemia; hypertension; in-hospital mortality; major clinical study; male; middle aged; mortality; out of hospital cardiac arrest; percutaneous coronary intervention; reperfusion; retrospective study; ST segment elevation myocardial infarction; stent thrombosis; thrombectomy
Cita
de Luca G,Algowhary M,Uguz B,de Oliveira DC,Ganyukov V,Zimbakov Z,Cercek M,Jensen L,Loh PH,Câlmâc L,Roura i Ferrer G,de Quadros A,Milewski M,Scotto Di Uccio F,von C,Versaci F,Ten J,Casella G,Wong Sung Lung A,Kala P,DÍEZ JL,Carrillo X,Dirksen M,Becerra VM,Kang M,Juzar DA,de Moura R,de Simone C,Milicic D,Davlouros P,Bakraceski N,Zilio F,Donazzan L,Kraaijeveld A,Galasso G,Arpad L,Marinucci L,Guiducci V,Menichelli M,Scoccia A,Yamaç AH,Ugur K,Flores X,Kovárník T,Kidawa M,Moreu J,Flavien V,Fabris E,Lozano Martínez I,Boccalatte M,Bosa F,Arellano C,Caiazzo G,Cirrincione G,Kao H-L,Sanchís J,Vignali L,Pereira H,Manzo S,Ordonez S,Arat A,Scheller B,Lehtola H,Teles R,Mantis C,Antti Y,Brum JA,Bessonov I,Zoni R,Savonitto S,Kochiadakis G,Alexopoulos D,Uribe CE,Kanakakis J,Faurie B,Gabrielli G,Gutiérrez A,Bachini JP,Rocha A,Tam FC-C,Rodriguez A,Lukito AA,Bellemain A,Pessah G,Cortese G,Parodi G,Burgadha MA,Kedhi E,Lamelas P,Suryapranata H,Nardin M,Verdoia M. SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion. Angiology. 2023. 74. (10):p. 987-996. IF:2,600. (2).