Portal de investigación
Clinical outcomes of percutaneous coronary interventions after transcatheter aortic valve replacement.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Pivato CA
- Cozzi O
- Fontana N
- Ieva F
- Condorelli G
- Godino C
- Reimers B
- Nakase M
- Hug K
- Rheude T
- Munoz-Garcia AJ
- Jimenez Diaz VA
- Ielasi A
- Barbanti M
- Biasco L
- Mylotte D
- Leoncini M
- de la Torre Hernandez JM
- Quadri G
- Varbella F
- Anzuini A
- Lopez D
- Garot P
- Brouwer J
- Mangieri A
- Regazzoli D
- Testa L
- Tomii D
- Chieffo A
- Joner M
- Sardella G
- Cerrato E
- Nombela-Franco L
- Pilgrim T
- Stefanini G
Grupos
Abstract
AIMS: The number of patients undergoing percutaneous coronary interventions (PCI) after transcatheter aortic valve replacement (TAVR) is expected to increase, but their prognosis remains poorly understood. METHODS AND RESULTS: Consecutive PCI patients with prior TAVR were compared to patients without prior TAVR between 2008 and 2023. The Kaplan-Meier method was used to estimate the 1-year incidence of major adverse cardiovascular events (MACE), defined as a composite of cardiovascular death or myocardial infarction. An entropy balance approach was implemented to adjust for imbalances in patient and procedural characteristics. Adjusted hazard ratios (HRs) were estimated using weighted Cox regression models. Comparing 420 PCI patients with prior TAVR (mean age 80.8 years, 37.1% women) to 1197 without (mean age 70.4 years, 24.6% women), 1-year MACE was higher in the prior TAVR group (8.7 vs. 3.7%; unadjusted HR 2.35, 95% CI 1.49-3.69; P < 0.001). After adjustment for clinical and procedural characteristics, prior TAVR remained associated with an increased risk of MACE (adjusted HR 2.36, 95% CI 1.08-5.16; P = 0.032). This was primarily driven by higher cardiovascular death (adjusted HR 3.12, 95% CI 1.10-8.79, P = 0.032), while the association with myocardial infarction was attenuated post-adjustment and no longer statistically significant. CONCLUSION: Patients undergoing PCI after TAVR experience a higher incidence of MACE compared to those undergoing PCI without prior TAVR, underscoring the importance of accurate patient selection before performing PCI in patients with chronic coronary syndrome and history of TAVR.
© The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology.
Datos de la publicación
- ISSN/ISSNe:
- 2752-4191, 2752-4191
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 40980722
European Heart Journal Open OXFORD UNIV PRESS
Citas Recibidas en Web of Science: 1
Documentos
Filiaciones
Keywords
- Aortic stenosis; Coronary artery disease; PCI; TAVR
Cita
Pivato CA,Cozzi O,Fontana N,Ieva F,Condorelli G,Godino C,Reimers B,Nakase M,Hug K,Rheude T,Munoz AJ,Jimenez VA,Ielasi A,Barbanti M,Biasco L,Mylotte D,Leoncini M,de la Torre JM,Quadri G,Varbella F,Anzuini A,Lopez D,Garot P,Brouwer J,Mangieri A,Regazzoli D,Testa L,SANZ J,Tomii D,Chieffo A,Joner M,Sardella G,Cerrato E,Nombela L,Pilgrim T,Stefanini G. Clinical outcomes of percutaneous coronary interventions after transcatheter aortic valve replacement. Eur. Heart J. Open. 2025. 5. (5):oeaf095. IF:4,300. (2).