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Maternal plasma cell-free RNA as a predictor of early and late-onset preeclampsia throughout pregnancy.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Castillo-Marco N
  • Cordero T
  • Igual M
  • Muñoz-Blat I
  • Gómez-Álvarez C
  • Bernat-González N
  • Gaspar-Doménech Á
  • Ortiz-Domingo É
  • Vives A
  • Ortega-Sanchís S
  • Volkov P
  • Delgado JL
  • Hernandez-Hernandez L
  • Canovas E
  • Gil MDM
  • Santacruz B
  • Gonzalez-Gonzalez NL
  • Plasencia W
  • Palacios-Marqués AM
  • Melchor Í
  • Martin-Martinez A
  • Benitez-Delgado T
  • PREMOM Consortium
  • Simón C
  • Garrido-Gómez T

Grupos

Abstract

Early- and late-onset preeclampsia (EOPE and LOPE) pose serious maternal-fetal risks, yet non-invasive early prediction remains challenging. In a prospective cohort of 9,586 pregnancies, we analyze trimester-specific plasma cell-free RNA (cfRNA) profiles from 42 EOPE and 43 LOPE cases versus 131 normotensive controls. Organ-specific transcriptomic shifts distinguish EOPE from LOPE. Predictive models based on cfRNA signatures identify EOPE up to 18.0 weeks before clinical onset in the first-trimester (T1) (AUC = 0.88), and 8.5 weeks in the second trimester (T2) (AUC = 0.89). LOPE is predicted 14.9 weeks in advance using T2 data (AUC = 0.90), while T1 performance is lower (AUC = 0.68). External validation confirms robust EOPE prediction (AUC = 0.87 at T1; 0.81 at T2) and acceptable LOPE performance (AUC = 0.63 at T1; AUC = 0.77 at T2). EOPE models are enriched for decidual transcripts, suggesting early maternal involvement; LOPE models reflect broader tissue contributions. These findings offer a path to early, non-invasive, subtype-specific preeclampsia risk stratification and prevention.

© 2025. The Author(s).

Datos de la publicación

ISSN/ISSNe:
2041-1723, 2041-1723

Nature Communications  NATURE PORTFOLIO

Tipo:
Article
Páginas:
9208-9208
PubMed:
41115885
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
4,846 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 5

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Keywords

  • Adult; Biomarkers; Case-Control Studies; Cell-Free Nucleic Acids; Female; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Prospective Studies; Transcriptome; RNA; transcriptome; biological marker; cell free nucleic acid; transcriptome; cell; health risk; maternal health; plasma; pregnancy; RNA; adult; Article; blood sampling; body mass; brain function; cesarean section; cohort analysis; controlled study; disease exacerbation; female; fetus; fetus risk; fetus weight; first trimester pregnancy; gene ontology; heart function; human; major clinical study; male; maternal age; maternal plasma; overrepresentation analysis; parity; plasma cell; predictive model; preeclampsia; pregnancy; pregnancy outcome; pregnant woman; premature labor; prematurity; risk assessment; second trimester pregnancy; sensitivity and specificity; small for gestational age; blood; case control study; diagnosis; genetics; pregnancy; prospective study

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