Analytical model of large-diameter spherical-like catheter for pulsed field ablation in treating cardiac arrhythmias.

Autores de IIS La Fe

• María Teresa Izquierdo De Francisco

  Autor

Participantes ajenos a IIS La Fe

• Pérez JJ
• González-Suárez A

Grupos

• Grupo de Investigación Clínica y Traslacional en Cardiología

Abstract

Objective.To study the electrical performance of large-diameter spherical-like catheters used for pulsed field ablation (PFA) in treating cardiac arrhythmias, especially evaluating the effect of electrode radius, applied voltage and maximum current delivered on the PFA-induced lesion depth.Approach.An analytical model was proposed which used spherical coordinates to estimate the value of the electric field around a spherical metal electrode. Lesion depth was estimated by the myocardium lethal electric field threshold. The paper also reviews the literature and proposes a relationship between this threshold and the total cumulative duration of the pulses applied during PFA.Main results.Despite the model´s simplicity in geometric terms, the estimated values of baseline impedance (44 O) and impedance drop due to PFA (7-9 O) are closely related to those observed in experimental studies (43 O and 5-7 O, respectively). The PFA-induced lesion size potentially increases with the applied voltage, but this is only true if the generator can provide the electrical current needed to maintain the required voltage. A nonlinear relationship was identified between PFA-induced lesion depth and the electrode diameter, which was also modulated by the total duration.Significance.The analytical model offers a physical explanation for the PFA-Induced electrical phenomenon, while emphasising how certain technical characteristics (maximum current, applied voltage, electrode diameter) can affect the depth of the lesion.

Creative Commons Attribution license.

Keywords

• analytical model; arrhythmias; cardiac ablation; electroporation; pulsed field ablation; spherical electrode