Portal de investigación
Sex Disparities in Neonatal Arterial Ischemic Stroke: Larger Lesion Volume and More Severe Long-Term Disability in Male Infants.
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- García-Alix A
- Núñez C
- Arca G
- Arnaez J
- Agut T
- Cordeiro M
- Benavente-Fernández I
- Lubián S
- Valverde E
- Stephan-Otto C
Grupos
Abstract
BACKGROUND: To examine the relationship between sex and infarct volume in neonatal arterial ischemic stroke (NAIS) and to compare the functional outcomes of male and female infants at 2 years of age. METHODS: A prospective observational multicenter study was conducted in 6 hospitals in Spain. Sixty-four consecutive infants with idiopathic and symptomatic NAIS were recruited. Lesion masks were created to determine NAIS volume and location. Data on acute-phase symptoms, including seizure occurrence and anticonvulsant drugs used and functional outcomes at 2 years, including need for speech therapy, were collected. Dichotomous categorical variables were compared between males and females using chi-square or logistic regression tests, while differences in continuous variables were assessed by means of t-tests. Analysis of covariance or logistic regression was performed to adjust for infarct volume. RESULTS: Male infants presented a higher prevalence of NAIS compared to females (61% vs 39%). In addition, males showed larger infarct volumes and a differential pattern in the spatial distribution of lesions (P < 0.05). The male group also presented higher rates of postnatal epilepsy (41% vs 12%; P = 0.019), need for speech therapy (58% vs 24%; P = 0.010), and strabismus at 2 years of age (18% vs 0%). CONCLUSIONS: Our results point to larger infarct volumes and a worse outcome in males affected by NAIS. These results, together with further studies on the differential effects associated with sex in the context of NAIS, may shape new sex-specific neuroprotective strategies and follow-up plans.
Copyright © 2025 Elsevier Inc. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0887-8994, 1873-5150
- Tipo:
- Article
- Páginas:
- 130-138
- PubMed:
- 41344166
- Enlace a otro recurso:
- www.scopus.com
- Factor de Impacto:
- 0,764 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
PEDIATRIC NEUROLOGY ELSEVIER SCIENCE INC
Citas Recibidas en Web of Science: 2
Documentos
- No hay documentos
Filiaciones
Keywords
- Brain volume; Cerebral palsy; Epilepsy; Ischemic arterial stroke; Neonate; Neurodevelopment; Speech therapy; Strabismus
Cita
García A,Núñez C,Arca G,Arnaez J,Agut T,Cordeiro M,BORONAT N,Benavente I,Lubián S,Valverde E,Stephan C. Sex Disparities in Neonatal Arterial Ischemic Stroke: Larger Lesion Volume and More Severe Long-Term Disability in Male Infants. Pediatr. Neurol. 2026. 175. p. 130-138. IF:2,000. (2).