1. Inicio
  2. Publicaciones
  3. Processing speed mediates the relationship between DDR1 and psychosocial functioning in euthymic patients with bipolar disorder presenting psychotic symptoms

Processing speed mediates the relationship between DDR1 and psychosocial functioning in euthymic patients with bipolar disorder presenting psychotic symptoms

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Aranda, S
  • Jiménez, E
  • Canales-Rodríguez, EJ
  • Verdolini, N
  • Alonso, S
  • Sepúlveda, E
  • Julià, A
  • Marsal, S
  • Bobes, J
  • Sáiz, PA
  • García-Portilla, P
  • Menchón, JM
  • Crespo, JM
  • González-Pinto, A
  • Pérez, V
  • Arango, C
  • Sanjuán, J
  • Pomarol-Clotet, E
  • Vieta, E
  • Vilella, E

Grupos

Abstract

The DDR1 locus is associated with the diagnosis of schizophrenia and with processing speed in patients with schizophrenia and first-episode psychosis. Here, we investigated whether DDR1 variants are associated with bipolar disorder (BD) features. First, we performed a case-control association study comparing DDR1 variants between patients with BD and healthy controls. Second, we performed linear regression analyses to assess the associations of DDR1 variants with neurocognitive domains and psychosocial functioning. Third, we conducted a mediation analysis to explore whether neurocognitive impairment mediated the association between DDR1 variants and psychosocial functioning in patients with BD. Finally, we studied the association between DDR1 variants and white matter microstructure. We did not find any statistically significant associations in the case-control association study; however, we found that the combined genotypes rs1264323AA-rs2267641AC/CC were associated with worse neurocognitive performance in patients with BD with psychotic symptoms. In addition, the combined genotypes rs1264323AA-rs2267641AC/CC were associated with worse psychosocial functioning through processing speed. We did not find correlations between white matter microstructure abnormalities and the neurocognitive domains associated with the combined genotypes rs1264323AA-rs2267641AC/CC. Overall, the results suggest that DDR1 may be a marker of worse neurocognitive performance and psychosocial functioning in patients with BD, specifically those with psychotic symptoms.

Datos de la publicación

ISSN/ISSNe:
1359-4184, 1476-5578

MOLECULAR PSYCHIATRY  SPRINGERNATURE

Tipo:
Article
Páginas:
2050-2058
PubMed:
38374360
Factor de Impacto:
4,390 SCImago ℠
Cuartil:
Q1 SCImago ℠

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Cita

Compartir