Portal de investigación
Uninterrupted direct-acting oral anticoagulation in patients undergoing transradial percutaneous coronary procedures: The DOAC-NOSTOP study rationale and design
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Calderón, AT
- Chiarito, M
- Santos, IA
- Cao, DVD
- Montilla, BV
- Román, AJ
- Garrido, PP
- Tartaglia, F
- García-García, HM
Grupos
Abstract
Background: patients with atrial fibrillation (AF) under treatment with chronic oral anticoagulation (OAC) often require coronary angiography with or without percutaneous coronary intervention (PCI). Deciding the management of OAC during this periprocedural period requires balancing the risks of hemorrhage and thrombotic complications. Guidelines recommend an uninterrupted strategy in patients receiving Vitamin-K Antagonists (VKA). However, for patients undergoing coronary angiography or PCI while on direct oral anticoagulants (DOACs), withdrawal 12-24 h prior to the procedure is still recommended. This is based on expert opinions given the lack of evidence. Therefore, whether DOAC discontinuation prior to trans-radial coronary procedures should be the strategy of choice is a matter of debate and solid evidence is needed to guide clinical decision making. Methods: The DOAC-NOSTOP study is a prospective, single-arm, open-label study evaluating the safety of DOACs continuation in 200 patients undergoing transradial percutaneous coronary procedures. DOAC treatment will not be interrupted throughout the periprocedural period. Primary outcome will be Bleeding Academic Research Consortium (BARC) type 2, 3, or 5 events, assessed at a 30-day follow-up. Conclusions: The DOAC-NOSTOP is the first study prospectively assessing the risk of bleeding with uninterrupted DOAC in patients undergoing trans-radial percutaneous coronary procedures.
Datos de la publicación
- ISSN/ISSNe:
- 1553-8389, 1878-0938
- Tipo:
- Article
- Páginas:
- 68-72
- PubMed:
- 38307792
- Factor de Impacto:
- 0,486 SCImago ℠
- Cuartil:
- Q3 SCImago ℠
Cardiovascular Revascularization Medicine ELSEVIER INC
Citas Recibidas en Web of Science: 3
Documentos
- No hay documentos
Filiaciones
Keywords
- Direct -acting oral anticoagulation; Trans -radial access; Percutaneous coronary intervention; Safety study
Cita
Calderón AT,Chiarito M,Santos IA,Cao DVD,Montilla BV,Román AJ,Garrido PP,Tartaglia F,García HM,DÍEZ JL,SANZ J. Uninterrupted direct-acting oral anticoagulation in patients undergoing transradial percutaneous coronary procedures: The DOAC-NOSTOP study rationale and design. Cardiovasc Revasc Med. 2024. 63. p. 68-72. IF:2,100. (3).