Portal de investigación
Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Comabella, M
- Hegen, H
- Villar, LM
- Rejdak, K
- Sao-Avilés, A
- Behrens, M
- Sastre-Garriga, J
- Mongay, N
- Berek, K
- Martínez-Yelamos, S
- Abdelhak, A
- Bachhuber, F
- Tumani, H
- Lycke, J
- Carbonell-Mirabent, P
- Valls-Carbo, A
- Rosenstein, I
- Alvarez-Lafuente, R
- Castillo-Triviño, T
- Otaegui, D
- Llufriu, S
- Blanco, Y
- Sánchez-López, AJ
- García-Merino, A
- Fissolo, N
- Gutiérrez, L
- Villacieros-alvarez, J
- Monreal, E
- Wiendl, H
- Montalban, X
- Lünemann, JD
Grupos
Abstract
Background and objectivesThe impact of viral infections on disease susceptibility and progression has predominantly been studied in patients with relapse-onset MS (RMS). Here, we determined immune responses to ubiquitous viruses in patients with primary progressive MS (PPMS).MethodsAntibody responses to Epstein-Barr virus (EBV), specifically to the latent EBV nuclear antigen 1 and the lytic viral capsid antigen VCA, human herpesvirus 6 (HHV-6), human cytomegalovirus (HCMV), and measles virus were determined in a cohort of 68 PPMS patients with a mean follow-up of 8 years and compared with 66 healthy controls matched for sex and age.ResultsCompared with controls, PPMS patients showed increased humoral immune responses to the EBV-encoded nuclear antigen-1 (EBNA1), but not to the lytic EBV capsid antigen (VCA) or to other viral antigens. Seroprevalence rates for HCMV were significantly higher in PPMS. Antiviral immune responses at baseline did not correlate with disability progression over time.DiscussionElevated immune responses toward EBNA1 are selectively increased in people with primary progressive disease, indicating a link between EBNA1-targeting immune responses and the development of both RMS and PPMS. Our data also suggest that chronic HCMV infection is associated with progressive MS.
Datos de la publicación
- ISSN/ISSNe:
- 0340-5354, 1432-1459
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 39666032
- Factor de Impacto:
- 1,359 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
JOURNAL OF NEUROLOGY SPRINGER HEIDELBERG
Citas Recibidas en Web of Science: 8
Documentos
- No hay documentos
Filiaciones
Keywords
- Multiple sclerosis; Primary progressive; Virus; Epstein-Barr virus; Human cytomegalovirus
Cita
Comabella M,Hegen H,Villar LM,Rejdak K,Sao A,Behrens M,Sastre J,Mongay N,Berek K,Martínez S,PÉREZ F,Abdelhak A,Bachhuber F,Tumani H,Lycke J,Carbonell P,Valls A,Rosenstein I,Alvarez R,Castillo T,Otaegui D,Llufriu S,Blanco Y,Sánchez AJ,García A,Fissolo N,Gutiérrez L,Villacieros J,Monreal E,Wiendl H,Montalban X,Lünemann JD. Increased EBNA1-specific antibody response in primary-progressive multiple sclerosis. J. Neurol. 2025. 272. (1):26. IF:5,400. (1).