Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature.

Autores de IIS La Fe

• Héctor Balastegui Martín

  Autor

Participantes ajenos a IIS La Fe

• Salas Sánchez M
• García-Martínez E
• Durán-García ME
• Lavilla Olleros C

Grupos

• Investigacion clínica en enfermedades crónicas e Infección por el VIH

Abstract

Cryopyrin-associated periodic syndrome is a rare autoinflammatory syndrome caused by a dysregulation of cytokine signaling pathways, particularly of the interleukin-1ß production. Symptoms typical appear early in life and include recurrent fever, arthralgia, and cutaneous rash, often accompanied by systemic manifestations and progressive end-organ damage resulting from chronic inflammation. Interleukin- targeted therapy constitutes the basis for treatment, and can lead to complete resolution of symptoms. We report a case of a 66-year-old man with cryopyrin-associated periodic syndrome related to V198M mutation, successfully treated with anakinra, an interleukin- 1 inhibitor frequently used in rheumatoid arthritis.

Copyright © 2025 Salas Sánchez, García-Martínez, Balastegui Martín, Durán-García and Lavilla Olleros.

Keywords

• CAPS; anakinra; autoinflammatory disease; case report; cryopyrin-associated periodic syndrome