Does Varicocele Repair Improve Conventional Semen Parameters? A Meta-Analytic Study of Before-After Data.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Cannarella R
  • Shah R
  • Hamoda TAA
  • Boitrelle F
  • Saleh R
  • Gul M
  • Rambhatla A
  • Kavoussi P
  • Toprak T
  • Harraz AM
  • Ko E
  • Çeker G
  • Durairajanayagam D
  • Alkahidi N
  • Kuroda S
  • Crafa A
  • Henkel R
  • Salvio G
  • Hazir B
  • Darbandi M
  • Bendayan M
  • Darbandi S
  • Falcone M
  • Kosgi R
  • Sawaid Kaiyal R
  • Karna K
  • Phuoc NHV
  • Birowo P
  • Colpi GM
  • de la Rosette J
  • Pinggera GM
  • Nguyen Q
  • Zini A
  • Zohdy W
  • Singh R
  • Saini P
  • Glina S
  • Lin H
  • Mostafa T
  • Rojas-Cruz C
  • Arafa M
  • Calogero AE
  • Dimitriadis F
  • Kothari P
  • Karthikeyan VS
  • Okada K
  • Chiba K
  • Kadioglu A
  • Altay B
  • Turunc T
  • Zilaitiene B
  • Gokalp F
  • Adamyan A
  • Katz D
  • Chung E
  • Mierzwa TC
  • Zylbersztejn DS
  • Paul GM
  • Sofikitis N
  • Sokolakis I
  • Malhotra V
  • Brodjonegoro SR
  • Adriansjah R
  • Tsujimura A
  • Amano T
  • Balercia G
  • Ziouziou I
  • Deswanto IA
  • Martinez M
  • Park HJ
  • Bakircioglu ME
  • Ceyhan E
  • Aydos K
  • Ramsay J
  • Minhas S
  • Al Hashimi M
  • Ghayda RA
  • Tadros N
  • Sindhwani P
  • Ho CCK
  • Rachman RI
  • Rodriguez Pena M
  • Motawi A
  • Ponnusamy AK
  • Dipankar S
  • Amir A
  • Binsaleh S
  • Serefoglu EC
  • Banthia R
  • Khalafalla K
  • Basukarno A
  • Bac NH
  • Singla K
  • Ambar RF
  • Makarounis K
  • Priyadarshi S
  • Duarsa GWK
  • Atmoko W
  • Jindal S
  • Arianto E
  • Akhavizadegan H
  • El Bardisi H
  • Shoshany O
  • Busetto GM
  • Moussa M
  • Jamali M
  • Al-Marhoon MS
  • Ruzaev M
  • Farsi HMA
  • Mutambirwa S
  • Lee DS
  • Kulaksiz D
  • Cheng YS
  • Bouzouita A
  • Sarikaya S
  • Kandil H
  • Tsampoukas G
  • Farkouh A
  • Bowa K
  • Savira M
  • Mogharabian N
  • Le TV
  • Harjanggi M
  • Anh DT
  • Long TQT
  • Soebadi MA
  • Hakim L
  • Tanic M
  • Ari UC
  • Parikh FR
  • Calik G
  • Kv V
  • Dorji G
  • Rezano A
  • Rajmil O
  • Tien DMB
  • Yuan Y
  • Lizarraga-Salas JF
  • Eze B
  • Ngoo KS
  • Lee J
  • Arslan U
  • Agarwal A
  • Global Andrology Forum

Grupos

Abstract

PURPOSE: The purpose of this meta-analysis is to study the impact of varicocele repair in the largest cohort of infertile males with clinical varicocele by including all available studies, with no language restrictions, comparing intra-person conventional semen parameters before and after the repair of varicoceles. MATERIALS AND METHODS: The meta-analysis was performed according to PRISMA-P and MOOSE guidelines. A systematic search was performed in Scopus, PubMed, Cochrane, and Embase databases. Eligible studies were selected according to the PICOS model (Population: infertile male patients with clinical varicocele; Intervention: varicocele repair; Comparison: intra-person before-after varicocele repair; Outcome: conventional semen parameters; Study type: randomized controlled trials [RCTs], observational and case-control studies). RESULTS: Out of 1,632 screened abstracts, 351 articles (23 RCTs, 292 observational, and 36 case-control studies) were included in the quantitative analysis. The before-and-after analysis showed significant improvements in all semen parameters after varicocele repair (except sperm vitality); semen volume: standardized mean difference (SMD) 0.203, 95% CI: 0.129-0.278; p<0.001; I²=83.62%, Egger's p=0.3329; sperm concentration: SMD 1.590, 95% CI: 1.474-1.706; p<0.001; I²=97.86%, Egger's p<0.0001; total sperm count: SMD 1.824, 95% CI: 1.526-2.121; p<0.001; I²=97.88%, Egger's p=0.0063; total motile sperm count: SMD 1.643, 95% CI: 1.318-1.968; p<0.001; I²=98.65%, Egger's p=0.0003; progressive sperm motility: SMD 1.845, 95% CI: 1.537%-2.153%; p<0.001; I²=98.97%, Egger's p<0.0001; total sperm motility: SMD 1.613, 95% CI 1.467%-1.759%; p<0.001; l2=97.98%, Egger's p<0.001; sperm morphology: SMD 1.066, 95% CI 0.992%-1.211%; p<0.001; I²=97.87%, Egger's p=0.1864. CONCLUSIONS: The current meta-analysis is the largest to date using paired analysis on varicocele patients. In the current meta-analysis, almost all conventional semen parameters improved significantly following varicocele repair in infertile patients with clinical varicocele.

Copyright © 2024 Korean Society for Sexual Medicine and Andrology.

Datos de la publicación

ISSN/ISSNe:
2287-4208, 2287-4690

World Journal of Mens Health  KOREAN SOC SEXUAL MEDICINE & ANDROLOGY

Tipo:
Article
Páginas:
92-132
PubMed:
37382284
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
0,788 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 33

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Keywords

  • Controlled before-after studies; Infertility, male; Meta-analysis; Varicocele

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