Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis.

Fecha de publicación: 01/01/2015

Autores de IIS La Fe

• Jose Juan Mondejar Garcia

  Autor

• David Salom Alonso

  Autor

• Salvador García Delpech

  Autor

• Manuel Díaz Llopis

  Autor

Grupos

• Biomedicina Molecular, Celular y Genómica

  

  Leader

  José María Millán Salvador

Abstract

PURPOSE: To measure thrombopoietin (TPO) levels in the serum and aqueous humors of patients with noninfectious acute anterior uveitis. METHODS: A prospective, comparative, controlled study. Serum and aqueous humors were obtained from the eyes of 16 patients with noninfectious acute anterior uveitis. TPO levels were measured using an enzyme-linked immunosorbent assay (ELISA). The results obtained were compared with those of a control group. RESULTS: Serum concentrations of TPO were not significantly different between control individuals and patients with active anterior uveitis. Aqueous humor TPO levels were 54.46+/-16.24 pg/mL in the eyes of patients with uveitis, and 34.32+/-11.63 pg/mL in the eyes of controls. The difference between the two groups was significant (Mann-Whitney U-test for independent data, P=0.0008), with uveitis patients exhibiting significantly higher levels of TPO. CONCLUSION: The high levels of TPO in the aqueous humors of uveitis patients points toward a cytoprotective role of this factor in inflammatory repair processes and the recovery of tissue homeostasis.

Keywords

• TPO; acute anterior uveitis; aqueous humors; cytoprotective; serum; thrombopoietin