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Development and validation of the Neuro-Score: a specific scale to detect and monitor cognitive impairment in kidney or liver transplant recipients.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Moreso F
  • Pons Miñano JA
  • Sánchez Fructuoso A
  • Jacas C
  • Alegret M
  • Ferrer M
  • Colmenero J
  • Andrés Belmonte A
  • López Jiménez V
  • Pascual S
  • Mazuecos Blanca A
  • Cachero A
  • Rivero A
  • Crespo M
  • Cuadrado A
  • Caballero Marcos A
  • Gonzalez Diéguez ML
  • Almohalla Alvarez C
  • Maruri Kareaga N
  • Alamo Martinez JM
  • Pagano G
  • Nuño Santana E
  • Torres IB
  • Pérez Flores I
  • Alonso-Titos J
  • Rodríguez-Soler M
  • Martinez Alarcón L
  • García Álvarez TM
  • Gonzalez-Vilatarsana E
  • Miras F
  • Gómez Bravo MA

Abstract

We created and validated the Neuro-Score, a specific scale to detect and monitor cognitive impairment, including mild stages, in kidney or liver transplant recipients. A qualitative study was conducted to define a preliminary set of 62 items. Item reduction was performed using exploratory factor analysis. Confirmatory factor analysis assessed the adequacy of the factorial solution. The total scores of the Neuro-Score and mini-mental state examination were compared. Responsiveness to change was evaluated from visit 1 (baseline) to 2A (18 months later) and temporal stability from visit 2A to 2B (1-2 weeks later). Factor analysis showed 11 factors with an eigenvalue of >1. Confirmatory factor analysis yielded a logical solution with 1 factor and 11 items that explained 27.9% of the variance. The final model showed satisfactory internal consistency (Cronbach a = 0.82). A weak negative correlation was found between Neuro-Score and mini-mental state examination total scores (Pearson r = -0.12; P = .0095). The Neuro-Score responsiveness to change was demonstrated (P = .022). No significant differences in the total score were observed between visits 2A and 2B, supporting the Neuro-Score temporal stability. The Neuro-Score scale is a simple, reliable, self-administered, easy-to-interpret, and consistent 11-item scale to detect and monitor cognitive impairment in kidney and liver transplant recipients.

Copyright © 2025. Published by Elsevier Inc.

Datos de la publicación

ISSN/ISSNe:
1600-6135, 1600-6143

AMERICAN JOURNAL OF TRANSPLANTATION  ELSEVIER SCIENCE INC

Tipo:
Article
Páginas:
1059-1069
PubMed:
39880125
Factor de Impacto:
3,311 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 1

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Keywords

  • cognitive impairment; kidney transplant; liver transplant; scale

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