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Galectins-1,-3 and-9 Are Present in Breast Milk and Have a Role in Early Life Development

Data de publicació:

Autors de IIS La Fe

Autors aliens a IIS La Fe

  • Rio-Aige, Karla
  • Girbal, Marina
  • Gonzalez, Sonia
  • Martinez-Costa, Cecilia
  • Castell, Margarida
  • Carmen Collado, Maria
  • Perez-Cano, Francisco J.
  • Rodriguez-Lagunas, Maria J.

Grups d'Investigació

Abstract

Galectins (Gal) are a family of conserved soluble proteins with high affinity for beta-galactoside structures. They have been recognized as important proteins for successful pregnancy. However, little is known about their presence in breast milk and their role in early infancy. Gal-1, -3 and -9 concentrations were evaluated by Multiplex immunoassays in mother-infant pairs from the MAMI cohort in maternal plasma (MP) (n = 15) and umbilical cord plasma (UCP) (n = 15) at birth and in breast milk samples (n = 23) at days 7 and 15 postpartum. Data regarding mother and infant characteristics were collected. Gal-9 was present in a lower concentration range than Gal-1 and Gal-3 in plasma, specifically in UCP. A major finding in the current study is that Gal-1, -3 and -9 were detected for the first time in all the transitional breast milk samples and no differences were found when comparing the two breastfeeding time points. Finally, Gal levels were associated with some maternal and infant characteristics, such as gestational age, pregnancy weight gain, maternal diet, the gender, infant growth and infant infections. In conclusion, Gal levels seem to be involved in certain developmental aspects of early life.

Dades de la publicació

ISSN/ISSNe:
2072-6643, 2072-6643

Nutrients  MDPI

Tipus:
Article
Pàgines:
-
PubMed:
36297023
Factor d'Impacte:
1,287 SCImago ℠
Quartil:
Q1 SCImago ℠

Cites Rebudes en Web of Science: 1

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Keywords

  • galectin; breast milk; umbilical cord plasma; maternal plasma

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