Characterization and prognostic implication of 17 chromosome abnormalities in myelodysplastic syndrome.

Autores de IIS La Fe

• Jordi Grau Hernandez

  Autor

• Fernando Carbonell Tatay

  Autor

• José Vicente Cervera Zamora

  Autor

• Maria José Calasanz Abinzano

  Autor

• Guillermo Sanz Santillana

  Autor

Participantes ajenos a IIS La Fe

• Sánchez-Castro J
• Marco-Betés V
• Gómez-Arbonés X
• Arenillas L
• Valcarcel D
• Vallespí T
• Costa D
• Nomdedeu B
• Jimenez MJ
• Granada I
• Ardanaz MT
• de la Serna J
• Sierra A
• Luño E
• Cervero CJ
• Falantes J
• González-Porrás JR
• Bailén A
• Amigo ML
• Solé F

Grupos

• Hematología y Hemoterapia

Abstract

The prognosis of chromosome 17 (chr17) abnormalities in patients with primary myelodysplastic syndrome (MDS) remains unclear. The revised International Prognostic Scoring System (IPSS-R) includes these abnormalities within the intermediate cytogenetic risk group. This study assessed the impact on overall survival (OS) and risk of acute myeloid leukemia transformation (AMLt) of chr17 abnormalities in 88 patients with primary MDS. We have compared this group with 1346 patients with primary MDS and abnormal karyotype without chr17 involved. The alterations of chr17 should be considered within group of poor prognosis. The different types of alterations of chromosome 17 behave different prognosis. The study confirms the intermediate prognostic impact of the i(17q), as stated in IPSS-R. The results of the study, however, provide valuable new information on the prognostic impact of alterations of chromosome 17 in complex karyotypes.