Clinical practice guidelines for the treatment of Ewing sarcoma (Spanish Sarcoma Research Group-GEIS).

Fecha de publicación: 19/08/2024 Fecha Ahead of Print: 19/08/2024

Autores de IIS La Fe

Erica Collado Ballesteros

Autor

Participantes ajenos a IIS La Fe

Mata Fernández C
Sebio A
Orcajo Rincón J
Martín Broto J
Martín Benlloch A
Marcilla Plaza D
López Pousa A
Gracia Alegría I
Giuppi M
Bernabeu D
de Alava E
Valverde Morales C

Abstract

Ewing sarcoma is a small round-cell sarcoma characterized by gene fusion involving EWSR1 (or another TET family protein like FUS) and an ETS family transcription factor. The estimated incidence of this rare bone tumor, which occurs most frequently in adolescents and young adults, is 0.3 per 100,000/year. Although only 25% of patients with Ewing sarcoma are diagnosed with metastatic disease, historical series show that this is a systemic disease. Patient management requires multimodal therapies-including intensive chemotherapy-in addition to local treatments (surgery and/or radiotherapy). In the recurrent/refractory disease setting, different approaches involving systemic treatments and local therapies are also recommended as well as patient inclusion in clinical trials whenever possible. Because of the complexity of Ewing sarcoma diagnosis and treatment, it should be carried out in specialized centers and treatment plans should be designed upfront by a multidisciplinary tumor board. These guidelines provide recommendations for diagnosis, staging, and multimodal treatment of Ewing sarcoma.

Datos de la publicación

ISSN/ISSNe:: 1699-048X, 1699-3055
Tipo:: Article
Páginas:: -
DOI:: 10.1007/s12094-024-03602-5
Factor de Impacto:: 0,764 SCImago ℠
Cuartil:: Q2 SCImago ℠

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Filiaciones

Mata Fernández C:: Pediatric and Adolescent Oncohaematology Unit, Hospital Materno-Infantil Gregorio, Marañón, Madrid, Spain
Sebio A:: Medical Oncology Department, Hospital Sant Pau, Barcelona, Spain
Orcajo Rincón J:: Nuclear Medicine Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain
Martín Broto J:: UAM), Madrid, Spain
Martín Benlloch A:: Section Spine Unit. Orthopaedic and Traumatology Department, Dr. Peset University Hospital, Valencia, Spain
Marcilla Plaza D:: Department of Pathology, Hospital Universitario Virgen del Rocío, Sevilla, Spain
López Pousa A:: Medical Oncology Department, Hospital Sant Pau, Barcelona, Spain
Gracia Alegría I:: Orthopaedic Oncology Unit, Orthoapedic and Traumatology Department, Hospital Sant Pau, Barcelona, Spain
Giuppi M:: Sarcoma patient, Madrid, Spain
Collado Ballesteros E:: Radiation Oncologist, Hospital Universitari i Politécnic La Fe , Valencia, Spain
Bernabeu D:: Chief of Musculo-skeletal Radiology Section, Radiodiagnosis Service Hospital General Universitario La Paz, Madrid, Spain
de Alava E:: Department of Normal and Pathological Cytology and Histology, School of Medicine, University of Seville, Institute of Biomedicine of Sevilla, IBiS/Virgen del Rocio University Hospital /CSIC/University of Sevilla/CIBERONC, Seville, Spain
Valverde Morales C:: Medical Oncology Department, Hospital Universitari Vall d´Hebrón, Barcelona, Spain