Verbal fluency in schizophrenia and bipolar disorder - A longitudinal, family study.

Data de publicació: 01/10/2024 Data Ahead of Print: 03/08/2024

Autors de IIS La Fe

Lorenzo Livianos Aldana

Autor

Autors aliens a IIS La Fe

Luperdi SC
Correa-Ghisays P
Vila-Francés J
Selva-Vera G
Tabarés-Seisdedos R
Balanzá-Martínez V

Grups d'Investigació

Investigación en Salud Mental

Leader

Ana Cristina García Blanco

Abstract

Verbal fluency (VF) has been proposed as a putative neurocognitive endophenotype in schizophrenia (SZ) and bipolar disorder (BD). However, this hypothesis has not been examined using a longitudinal family approach. We conducted a five-group, comparative study. The sample comprised 323 adult participants, including 81 BD patients, 47 unaffected relatives of BD BD-Rel), 76 SZ patients, 40 unaffected relatives of SZ (SZ-Rel), and 79 genetically unrelated healthy controls (HC). All subjects were assessed twice with semantic VF (sem-VF) and phonological VF (ph-VF) tests over a 2-year follow-up period. ANCOVAs controlling for age and years of education were used to compare performance across groups. Patients with SZ and BD and their unaffected relatives showed sem-VF and ph-VF deficits at baseline, which persisted over time (all, p < 0.05). Moreover, BD-Rel showed an intermediate performance between SZ and HC. A repeated-measures ANOVA revealed no significant differences in the between-group trajectories comparison (p > 0.05). Our findings support that VF may represent a neurocognitive endophenotype for SZ and BD. Further longitudinal, family studies are warranted to confirm this preliminary evidence.

Dades de la publicació

ISSN/ISSNe:: 0022-3956, 1879-1379
Tipus:: Article
Pàgines:: 33-40
DOI:: 10.1016/j.jpsychires.2024.07.056
PubMed:: 39121705
Factor d'Impacte:: 1,560 SCImago ℠
Quartil:: Q1 SCImago ℠

Documents

No hi ha documents

Mètriques

Filiacions

Luperdi SC:: Program in Medicine, University of Valencia, Avda Blasco Ibanez, 15, 46010, Valencia, Spain

Department of Psychiatry, Virgen de Los Lirios Hospital, Polígono de Caramanchel, s/n, 03804, Alcoi, Alicante, Spain
Correa-Ghisays P:: Faculty of Psychology, University of Valencia, Avda Blasco Ibañez, 21, 46010, Valencia, Spain

Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain

INCLIVA Health Research Institute, C. de Menéndez y Pelayo, 4, 46010, Valencia, Spain
Vila-Francés J:: IDAL - Intelligent Data Analysis Laboratory, University of Valencia, Avda de La Universitat s/n, 46100, Burjassot, Valencia, Spain
Selva-Vera G:: Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain

INCLIVA Health Research Institute, C. de Menéndez y Pelayo, 4, 46010, Valencia, Spain

Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Avda Blasco Ibáñez, 15, 46010, Valencia, Spain

Department of Psychiatry, University Clinical Hospital of Valencia, Avda Blasco Ibanez, 15, 46010, Valencia, Spain
Livianos L:: Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Avda Blasco Ibáñez, 15, 46010, Valencia, Spain

Department of Psychiatry, La Fe University and Polytechnic Hospital, Avda de Fernando Abril Martorell, 106, 46026, Valencia, Spain

Biomedical Research Networking Centre for Public Health (CIBERESP-Grupo 17), Instituto de Salud Carlos III, Avda. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain
Tabarés-Seisdedos R:: Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain

INCLIVA Health Research Institute, C. de Menéndez y Pelayo, 4, 46010, Valencia, Spain

Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Avda Blasco Ibáñez, 15, 46010, Valencia, Spain
Balanzá-Martínez V:: Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Av. Monforte de Lemos, 3-5. Pabellón 11. Planta 0, 28029, Madrid, Spain

INCLIVA Health Research Institute, C. de Menéndez y Pelayo, 4, 46010, Valencia, Spain

Teaching Unit of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia, Avda Blasco Ibáñez, 15, 46010, Valencia, Spain

VALSME (VALencia Salut Mental i Estigma) Research Group, University of Valencia, Valencia, Spain

Keywords

Cognitive functioning; Endophenotype; Family study; Fluency impairments; Follow-up. verbal fluency in schizophrenia and bipolar disorder – a longitudinal; Neurocognition; Unaffected relatives

Projectes associats

EFECTOS DE LA MONOTERAPIA CON LITIO EN EL FUNCIONAMIENTO NEUROPSICOLOGICO DE LOS PACIENTES CON TRASTORNO BIPOLAR

Investigador Principal: LORENZO LIVIANOS ALDANA

SM I 22/2011 . 2012

CON-CIENCIA-YV: PILDORAS DE SALUD

FCT-13-7457_FECYT_2013 . MINISTERIO DE ECONOMIA Y COMPETITIVIDAD; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2013