Portal de investigación
Unrelated Cord Blood Transplantation for Patients with Primary or Secondary Myelofibrosis
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Robin M
- Giannotti F
- Deconinck E
- Mohty M
- Michallet M
- Chevallier P
- Cahn JY
- Legrand F
- Rovira M
- Passweg J
- Sierra J
- Nguyen S
- Maillard N
- Yakoub-Agha I
- Linkesch W
- Cannell P
- Marcatti M
- Bay JO
- Chalandon Y
- Kröger N
- Gluckman E
- Rocha V
- Olavarria E
- Ruggeri A
- Eurocord and Chronic Malignancies Working Party-European Group for Blood and Mar
Grupos
Abstract
To determine whether umbilical cord blood transplantation (UCBT) is an alternative cure for myelofibrosis (MF), we evaluated 35 UCBTs reported to Eurocord. Seven patients had secondary acute myeloid leukemia (AML) at UCBT, and median age at UCBT was 54 years. Twenty-four patients received a reduced-intensity conditioning (RIC) regimen, and 17 of 35 patients received total body irradiation (2 to 12 Gy)-fludarabine-cyclophosphamide (TCF) conditioning. The median follow-up was 24 months. The cumulative incidence of neutrophil recovery at 60 days was 80%. Fifteen patients relapsed after UCBT. The 2-year overall survival and event-free-survival (EFS) rates were 44% and 30%, respectively. All patients given TCF achieved neutrophil and platelet recovery, and the use of TCF was associated with superior EFS in the RIC population (44% versus 0%, P =.001). Patients with transformation to AML had similar outcomes to patients with less advanced stages. In conclusion, despite graft failure remaining a major concern, the role of UCBT in the management of MF, especially using RIC TCF-based regimens, deserves further investigation to improve results. (C) 2014 American Society for Blood and Marrow Transplantation.
Datos de la publicación
- ISSN/ISSNe:
- 1083-8791, 1523-6536
- Tipo:
- Article
- Páginas:
- 1841-1846
- PubMed:
- 24946719
- Factor de Impacto:
- 1,946 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION ELSEVIER SCIENCE INC
Citas Recibidas en Web of Science: 44
Documentos
- No hay documentos
Filiaciones
Keywords
- Myelofibrosis; Umbilical cord blood transplantation
Campos de Estudio
Cita
Robin M,Giannotti F,Deconinck E,Mohty M,Michallet M,SANZ G,Chevallier P,Cahn JY,Legrand F,Rovira M,Passweg J,Sierra J,Nguyen S,Maillard N,Yakoub I,Linkesch W,Cannell P,Marcatti M,Bay JO,Chalandon Y,Kröger N,Gluckman E,Rocha V,Olavarria E,Ruggeri A,Eurocord and Chronic Malignancies Working Party M. Unrelated Cord Blood Transplantation for Patients with Primary or Secondary Myelofibrosis. Biol. Blood Marrow Transplant. 2014. 20. (11):p. 1841-1846. IF:3,404. (2).