Portal de investigación
Mitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Ergun Y
- Imamoglu AG
- Demirkiran C
- Basar M
- Garg A
- Yildirim RM
- Seli E
Grupos
Abstract
Mitochondrial unfolded protein stress response (mtUPR) plays a critical role in regulating cellular and metabolic stress response and helps maintain protein homeostasis. Caseinolytic peptidase P (CLPP) is one of the key regulators of mtUPR and promotes unfolded protein degradation. Previous studies demonstrated that global deletion of Clpp resulted in female infertility, whereas no impairment was found in the mouse model with targeted deletion of Clpp in cumulus/granulosa cells. These results suggest the need to delineate the function of Clpp in oocytes. In this study, we aimed to further explore the role of mtUPR in female reproductive competence and senescence using a mouse model. Oocyte-specific targeted deletion of Clpp in mice resulted in female subfertility associated with metabolic and functional abnormalities in oocytes, thus highlighting the importance of CLPP-mediated protein homeostasis in oocyte competence and reproductive function.
Datos de la publicación
- ISSN/ISSNe:
- 1661-6596, 1422-0067
- Tipo:
- Article
- Páginas:
- -
- DOI:
- 10.3390/ijms25031866
- PubMed:
- 38339144
- Factor de Impacto:
- 1,176 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES MDPI
Citas Recibidas en Web of Science: 6
Documentos
- No hay documentos
Filiaciones
Keywords
- mitochondrial stress response; mitochondrial dysfunction; female fertility; oocyte function; CLPP
Cita
Ergun Y,Imamoglu AG,COZZOLINO M,Demirkiran C,Basar M,Garg A,Yildirim RM,Seli E. Mitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility. Int. J. Mol. Sci. 2024. 25. (3):1866. IF:4,900. (1).