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  3. The role of bone marrow biopsy and FDG-PET/CT in identifying bone marrow infiltration in the initial diagnosis of high grade non-Hodgkin B-cell lymphoma and Hodgkin lymphoma. accuracy in a multicenter series of 372 patients

The role of bone marrow biopsy and FDG-PET/CT in identifying bone marrow infiltration in the initial diagnosis of high grade non-Hodgkin B-cell lymphoma and Hodgkin lymphoma. accuracy in a multicenter series of 372 patients

Fecha de publicación:

Autores de IIS La Fe

  • María Teresa Orero Castello

    Autor

  • Maria Jose Remigia Pellicer

    Autor

  • Alma Lancharro

    Autor

  • July Carolina Igua Saenz

    Autor

Participantes ajenos a IIS La Fe

  • Chen-Liang TH
  • Martin-Santos T
  • Jerez A
  • Muiña B
  • Romera M
  • Fernandez-Muñoz H
  • Raya JM
  • Fernandez-Gonzalez M
  • Villegas C
  • Carlos Herrera J
  • Frutos L
  • Luis Navarro J
  • Uña J
  • Sanchez-Vaño R
  • Cozar Mdel P
  • Contreras J
  • Sanchez-Blanco JJ
  • Perez-Ceballos E
  • Ortuño FJ

Grupos

Abstract

Bone marrow infiltration (BMI), categorized as an extra-nodal site, affects stage and is associated with poor prognosis in newly diagnosed lymphoma patients. We have evaluated the accuracy of PET/CT and bone marrow biopsy (BMB) to assess BMI in 372 lymphoma patients [140 Hodgkin Lymphoma (HL) and 232 High Grade B-cell non-Hodgkin Lymphoma (HG B-NHL), among them 155 Diffuse Large B-Cell Lymphoma (DLCL)]. For HL cases, and taking into account PET/CT, sensitivity, negative predictive value (NPV) and accuracy were 96.7, 99.3, and 99.3% while those of BMB were 32.3, 83.8, and 85%, respectively. For HG B-NHL and considering PET/CT, sensitivity, NPV, and accuracy were 52.7, 81.7, and 84.1%, while those of BMB were 77.6, 90.2, and 90.7%, respectively. In the HG B-NHL group, 25 patients would have been under-staged without BMB. These results lead us to recommend PET/CT and the avoidance of BMB to assess BMI in HL. In the case of HG B-NHL, bone marrow status should be assessed firstly by means of PET/CT; only in either focal or diffuse PET/CT with low borderline SUV max values or in negative cases, should BMB be carried out afterwards. In the HG B-NHL setting and at the present moment, both techniques are complementary. Am. J. Hematol. 90:686-690, 2015. (c) 2015 Wiley Periodicals, Inc.

Datos de la publicación

ISSN/ISSNe:
0361-8609, 1096-8652

AMERICAN JOURNAL OF HEMATOLOGY  WILEY

Tipo:
Article
Páginas:
686-690
PubMed:
25925613
Factor de Impacto:
1,798 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 46

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Keywords

  • POSITRON-EMISSION-TOMOGRAPHY; CLINICAL-SIGNIFICANCE; RESPONSE ASSESSMENT; INVOLVEMENT; METAANALYSIS; PERFORMANCE; PROVIDES; CT

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