Towards the personalization of septic shock resuscitation: the fundamentals of ANDROMEDA-SHOCK-2 trial.

Autores de IIS La Fe

• Gerardo Aguilar Aguilar

  Autor

• Paula Carmona García

  Autor

• Antonio Pérez Aytes

  Autor

Participantes ajenos a IIS La Fe

• Ramasco, F
• Aldecoa, C
• Bakker, J
• Dominguez, D
• Galiana, M
• Hernandez, G
• Kattan, E
• Olea, C
• Ospina-Tascon, G
• Ramos, K
• Ramos, S
• Tamayo, G
• Tuero, G
• ANDROMEDA-SHOCK-2, Spanish Investigators, Sociedad Espanola de
• Anestesiologia, Reanimacion y Terapeutica del Dolor (SEDAR)

Grupos

• Anestesia y Cuidados Críticos

  Investigador Principal

  María Azucena Pajares Moncho

• Medicina Perioperatoria, Anestesiología y Reanimación

  

  Leader

  Óscar Díaz Cambronero

Abstract

Septic shock is a highly lethal and prevalent disease. Progressive circulatory dysfunction leads to tissue hypoperfusion and hypoxia, eventually evolving to multiorgan dysfunction and death. Prompt resuscitation may revert these pathogenic mechanisms, restoring oxygen delivery and organ function. High heterogeneity exists among the determinants of circulatory dysfunction in septic shock, and current algorithms provide a stepwise and standardized approach to conduct resuscitation. This review provides the pathophysiological and clinical rationale behind ANDROMEDA-SHOCK-2, an ongoing multicenter randomized controlled trial that aims to compare a personalized resuscitation strategy based on clinical phenotyping and peripheral perfusion assessment, versus standard of care, in early septic shock resuscitation.

Copyright © 2024. Publicado por Elsevier España, S.L.U.

Keywords

• ANDROMEDA-SHOCK trial; Capillary refill time; Diastolic blood pressure; Ensayo ANDROMEDA-SHOCK; Fluid responsiveness; Presión arterial diastólica; Presión de pulso; Pulse pressure; Respuesta a líquidos; Sepsis; Septic shock; Shock séptico; Tiempo de llenado capilar