Diagnostic Accuracy of Abdominal CT for Locally Advanced Colon Tumors: Can We Really Entrust Certain Decisions to the Reliability of CT?

Autores de IIS La Fe

• Blas Flor Lorente

  Autor

Participantes ajenos a IIS La Fe

• Garcia Del Alamo Hernandez, Yaiza
• Cano-Valderrama, Oscar
• Cerdan-Santacruz, Carlos
• Pereira Perez, Fernando
• Aldrey Cao, Ines
• Nunez Fernandez, Sandra
• Alvarez Sarrado, Eduardo
• Obregon Reina, Rosangela
• Dujovne Lindenbaum, Paula
• Taboada Ameneiro, Maria
• Ambrona Zafra, David
• Perez Farre, Silvia
• Pascual Damieta, Marta
• Frago Montanuy, Ricardo
• Biondo, Sebastiano
• Collaborative Group For The Study Of Metachronous Peritoneal Metastases
• Of pT Colon Cancer

Grupos

• Cirugía digestiva y Cuidados perioperatorios

  

  Leader

  Matteo Frasson

Abstract

Many different options of neoadjuvant treatments for advanced colon cancer are emerging. An accurate preoperative staging is crucial to select the most appropriate treatment option. A retrospective study was carried out on a national series of operated patients with T4 tumors. Considering the anatomo-pathological analysis of the surgical specimen as the gold standard, a diagnostic accuracy study was carried out on the variables T and N staging and the presence of peritoneal metastases (M1c). The parameters calculated were sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios, as well as the overall accuracy. A total of 50 centers participated in the study in which 1950 patients were analyzed. The sensitivity of CT for correct staging of T4 colon tumors was 57%. Regarding N staging, the overall accuracy was 63%, with a sensitivity of 64% and a specificity of 62%; however, the positive and negative likelihood ratios were 1.7 and 0.58, respectively. For the diagnosis of peritoneal metastases, the accuracy was 94.8%, with a sensitivity of 40% and specificity of 98%; in the case of peritoneal metastases, the positive and negative likelihood ratios were 24.4 and 0.61, respectively. The diagnostic accuracy of CT in the setting of advanced colon cancer still has some shortcomings for accurate diagnosis of stage T4, correct classification of lymph nodes, and preoperative detection of peritoneal metastases.

Keywords

• advanced colon cancer; CT staging; diagnostic accuracy