Metabolomics 2022 workshop report: state of QA/QC best practices in LC-MS-based untargeted metabolomics, informed through mQACC community engagement initiatives.

Fecha de publicación: 08/11/2023 Fecha Ahead of Print: 08/11/2023

Autores de IIS La Fe

• Julia Kuligowski

  Autor

Participantes ajenos a IIS La Fe

• Dunn, Warwick B.
• Lewis, Matthew
• Mosley, Jonathan D.
• Schock, Tracey
• Ulmer Holland, Candice
• Zanetti, Krista A.
• Vuckovic, Dajana
• Metabolomics Quality Assurance and Quality Control Consortium (mQACC)

Grupos

• Perinatología

  

  Leader

  Máximo Vento Torres

Abstract

INTRODUCTION: The Metabolomics Quality Assurance and Quality Control Consortium (mQACC) organized a workshop during the Metabolomics 2022 conference. OBJECTIVES: The goal of the workshop was to disseminate recent findings from mQACC community-engagement efforts and to solicit feedback about a living guidance document of QA/QC best practices for untargeted LC-MS metabolomics. METHODS: Four QC-related topics were presented. RESULTS: During the discussion, participants expressed the need for detailed guidance on a broad range of QA/QC-related topics accompanied by use-cases. CONCLUSIONS: Ongoing efforts will continue to identify, catalog, harmonize, and disseminate QA/QC best practices, including outreach activities, to establish and continually update QA/QC guidelines.

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

• Metabolomics; Quality control (QC) samples; Liquid chromatography-mass spectrometry (LC-MS); Internal standards; Blanks; System suitability testing (SST); Analytical batch