Targeted cargo delivery in senescent cells using capped mesoporous silica nanoparticles.

Autores de IIS La Fe

• Ramón Martínez Máñez

  Autor

• María Dolores Marcos Martínez

  Autor

• Félix Sancenón Galarza

  Autor

• 

  Marta Moreno Torres

  Autor

• José Ramón Murguía Ibáñez

  Autor

Participantes ajenos a IIS La Fe

• Agostini A
• Mondragón L
• Bernardos A
• Soto J
• Costero A
• Manguan-García C
• Perona R
• Aparicio-Sanchis R

Abstract

Learning to let go with age: Intracellular controlled release of molecules within senescent cells was achieved using mesoporous silica nanoparticles (MSNs) capped with a galacto-oligosaccharide (GOS) to contain the cargo molecules (magenta spheres; see scheme). The GOS is a substrate of the senescent biomarker, senescence-associated ß-galactosidase (SA-ß-gal), and releases the cargo upon entry into SA-ß-gal expressing cells.