Objective Image Quality Comparison Between Brain-Dedicated PET and PET/CT Scanners.

Autores de IIS La Fe

• Maria Teresa Gandia Ferrero

  Autor

• 

  Irene Torres Espallardo

  Autor

• Begoña Martinez Sanchis

  Autor

• Pablo Sopena Novales

  Autor

• 

  Luis Martí Bonmatí

  Autor

Participantes ajenos a IIS La Fe

• Morera-Ballester C
• Muñoz E
• González-Pavón G

Grupos

• Investigacion Biomédica en Imagen (GIBI 2-30)

• Núcleo de investigación traslacional integrado Urológico de Valencia (NITIUV)

Abstract

As part of a clinical validation of a new brain-dedicated PET system (CMB), image quality of this scanner has been compared to that of a whole-body PET/CT scanner. To that goal, Hoffman phantom and patient data were obtined with both devices. Since CMB does not use a CT for attenuation correction (AC) which is crucial for PET images quality, this study includes the evaluation of CMB PET images using emission-based or CT-based attenuation maps. PET images were compared using 34 image quality metrics. Moreover, a neural network was used to evaluate the degree of agreement between both devices on the patients diagnosis prediction. Overall, results showed that CMB images have higher contrast and recovery coefficient but higher noise than PET/CT images. Although SUVr values presented statistically significant differences in many brain regions, relative differences were low. An asymmetry between left and right hemispheres, however, was identified. Even so, the variations between the two devices were minor. Finally, there is a greater similarity between PET/CT and CMB CT-based AC PET images than between PET/CT and the CMB emission-based AC PET images.

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords

• Attenuation correction; Brain dedicated PET; Image analysis; Image quality