Nailfold videocapillaroscopy patterns in systemic sclerosis: implications for cutaneous subsets, disease features and prognostic value for survival.

Fecha de publicación: 01/08/2023 Fecha Ahead of Print: 01/08/2023

Autores de IIS La Fe

• José Antonio Todolí Parra

  Autor

Participantes ajenos a IIS La Fe

• Tolosa-Vilella, Carles
• Del Mar Rodero-Roldan, Maria
• Guillen-Del-Castillo, Alfredo
• Marin-Ballve, Adela
• Boldova-Aguar, Rafael
• Mari-Alfonso, Begona
• Feijoo-Masso, Carlos
• Colunga-Arguelles, Dolores
• Rubio-Rivas, Manuel
• Trapiella-Martinez, Luis
• Iniesta-Arandia, Nerea
• Callejas-Moraga, Eduardo
• Garcia-Hernandez, Francisco J
• Saez-Comet, Luis
• Gonzalez-Echavarri, Cristina
• Ortego-Centeno, Norberto
• Freire, Mayka
• Vargas-Hitos, Jose Antonio
• Rios-Blanco, Juan J
• Rodriguez-Pinto, Ignasi
• Chamorro, Antonio-J
• Pla-Salas, Xavier
• Madronero-Vuelta, Ana Belen
• Ruiz-Munoz, Manuel
• Fonollosa-Pla, Vicent
• Simeon-Aznar, Carmen Pilar
• RESCLE Investigators

Grupos

• Investigacion clínica en enfermedades crónicas e Infección por el VIH

  Investigador establecido

  Marta Montero Alonso

Abstract

OBJECTIVES: To assess the associations and prognostic value of scleroderma patterns by nailfold videocapillaroscopy (NVC) in patients with systemic sclerosis (SSc) and cutaneous subsets. METHODS: At baseline, 1356 SSc patients from the RESCLE registry were compared according to the scleroderma pattern as Late pattern and non-Late pattern, which included Early and Active patterns. Patient characteristics, disease features, survival time and causes of death were analysed. RESULTS: Late pattern was identified in 540 (39.8%), and non-Late pattern in 816 (60.2%) patients (88% women; 987 lcSSc/251 dcSSc). Late pattern was associated to dcSSc (OR=1.96; p<0.001), interstitial lung disease (ILD) (OR=1.29; p=0.031), and scleroderma renal crisis (OR=3.46; p<0.001). Once the cutaneous subset was disregarded in an alternative analysis, both digital ulcers (DU) (OR=1.29; p<0.037) and anti-topoisomerase I antibodies (OR=1.39; p< 0.036) emerged associated with the Late pattern. By cutaneous subsets, associations with Late pattern were: (1) in dcSSc, acro-osteolysis (OR=2.13; p=0.022), and systolic pulmonary artery pressure >40 mmHg by Doppler echocardiogram (OR=2.24; p<0.001); and (2) in lcSSc, ILD (OR=1.38; p=0.028). Survival was reduced in dcSSc with Late pattern compared to non-Late pattern (p=0.049). Risk factors for SSc mortality in multivariate regression Cox analysis were age at diagnosis (HR=1.03; p<0.001), dcSSc (HR=2.48; p<0.001), DU (HR=1.38; p=0.046), ILD (HR=2.81; p<0.001), and pulmonary arterial hypertension (HR=1.99; p<0.001). CONCLUSIONS: SSc patients with Late pattern more frequently present dcSSc and develop more fibrotic and vascular manifestations. Advanced microangiopathy by NVC identifies dcSSc patients at risk of reduced survival due to SSc-related causes.

Keywords

• systemic sclerosis; nailfold videocapillaroscopy; limited cutaneous SSc; diffuse cutaneous SSc; organ involvement; survival