Portal de investigación
The impact of frailty on intra-hospital survival in older patients with COVID-19 infection: the importance of early identification. SEMI-COVID National Registry.
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Lopez-Sampalo, A
- Hernandez-Negrin, H
- Bernal-Lopez, M-R
- Rubio-Rivas, M
- Maria, Dolores Martin-Escalante
- Philip, Wikman-Jogersen
- Ana, Garcia-Reyne
- Martinez, Rosa Fernandez-Madera
- Gomez-Antunez, M
- Luis Beato-Perez, Jose
- David Torres-Pena, Jose
- Angel Martin-Oterino, Jose
- Loureiro-Amigo, J
- Vicente de la Sota, J
- Reboiro, Manuel Lorenzo-Lopez
- Bernal-Roman, B
- Fernandez-Sola, J
- Amoros-Martinez, F
- Vicente-Lopez, N
- Valle-Bernard, R
- Lopez-Ruiz, A
- Ramos-Rincon, J-M
- Gomez-Huelgas, R
Grupos
Abstract
BACKGROUND: Emerging evidence suggests that frailty may be a significant predictor of poor outcomes in older individuals hospitalized due to COVID-19. This study aims to determine the prognostic value of frailty on intrahospital patient survival. METHODS: This observational, multicenter, nationwide study included patients aged 70 years and older who were hospitalized due to COVID-19 in Spain between March 1 and December 31, 2020. Patient data were obtained from the SEMI-COVID-19 Registry of the Spanish Society of Internal Medicine. Frailty was assessed using the Clinical Frailty Scale. The primary outcome was hospital survival. Cox proportional hazards models were used to assess predictors of survival. RESULTS: A total of 1,878 participants (52% men and 48% women) were included, with 1,351 (71.9%) survivors and 527 (28.1%) non-survivors. The non-survivor group had higher mean age (83.5 vs. 81 years), comorbidities (6.3 vs. 5.3 points on the Charlson index), degree of dependency (26.8% vs. 12.4% severely dependent patients), and frailty (34.5% vs. 14.7% severely frail patients) compared to survivors. However, there were no differences in terms of sex. Our results demonstrate that a moderate-severe degree of frailty is the primary factor independently associated with shorter survival [HR 2.344 (1.437-3.823; p < 0.001) for CFS 5-6 and 3.694 (2.155-6.330; p < 0.001) for CFS 7-9]. CONCLUSION: Frailty is the main predictor of adverse outcomes in older patients with COVID-19. The utilization of tools such as the Clinical Frailty Scale is crucial for early detection in this population.
Copyright © 2023 Sociedad Española de Medicina Interna (SEMI). Published by Elsevier España, S.L.U. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 2254-8874, 2254-8874
- Tipo:
- Article
- Páginas:
- 461-469
- PubMed:
- 37454971
- Factor de Impacto:
- 0,123 SCImago ℠
Revista clinica espanola Elsevier Espana
Documentos
- No hay documentos
Filiaciones
Keywords
- COVID-19; fragilidad; frailty; older people; pacientes mayores.; prognosis; pronóstico; supervivencia; survival
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Investigador Principal: PATRICIA CORRECHER MEDINA
OBS14099 . 2018
MEMORIA PARA EL ESTUDIO DE ESPLENOMEGALIA Y PACIENTES ESPLENECTOMIZADOS NO FILIADOS EN POBLACIÓN INFANTIL Y ADULTA.
Investigador Principal: ISIDRO VITORIA MIÑANA
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Investigador Principal: MARTA MONTERO ALONSO
PANCOVID . 2020
Cita
Lopez A,Hernandez H,Bernal M-R,Rubio M,Maria DM,Philip W,Ana G,Martinez RF,Gomez M,Luis Beato J,David Torres J,Angel Martin J,Loureiro J,Vicente de la Sota J,GIL R,Reboiro ML,Bernal B,Fernandez J,Amoros F,Vicente N,Valle R,Lopez A,Ramos J-M,Gomez R. The impact of frailty on intra-hospital survival in older patients with COVID-19 infection: the importance of early identification. SEMI-COVID National Registry. Rev Clin Esp (Barc). 2023. 223. (8):p. 461-469.