Feasibility of a screening algorithm for chronic thromboembolic pulmonary hypertension: The OSIRIS study.

Fecha de publicación: 19/05/2023 Fecha Ahead of Print: 19/05/2023

Autores de IIS La Fe

• Carmen Fernández Rosell

  Autor

• Alberto García Ortega

  Autor

Participantes ajenos a IIS La Fe

• Otero, Remedios
• Lobo, Jose Luis
• Lopez, Raquel
• Jimenez, David
• Muriel, Alfonso
• Alfonso, Maria
• Ballaz, Aitor
• Nunez-Ares, Ana
• Rodriguez-Matute, Consolacion
• de Miguel-Diez, Javier
• Rodriguez-Chiaradia, Diego Agustin
• Alcalde, Mercedes
• Elias, Teresa
• Jara-Palomares, Luis
• Rivas, Agustina
• Alonso, Angel
• Sancho, Teresa
• Morillo, Raquel
• Garcia-Bragado, Fernando
• Hernandez-Blasco, Luis
• Uresandi, Fernando
• Madridano, Olga
• Aguero, Ramon
• Monreal, Manuel
• OSIRIS Investigators

Grupos

• Neumología

  

  Leader

  Miguel Ángel Martínez García

Abstract

INTRODUCTION: Chronic thromboembolic pulmonary hypertension (CTEPH) is a long-term sequel to pulmonary embolism (PE) whose incidence varies according to different published studies. We have carried out this study to determine its incidence within 2years after index pulmonary embolism and to study limitations to an early diagnosis. MATERIAL AND METHODS: OSIRIS is a multicentre, longitudinal cohort study. Patients were followed for 3, 6, 12, and 24months after pulmonary embolism using a structured three-step algorithm. A physician-centered questionnaire at least one positive response in a screening proceeded to the second step, transthoracic echocardiography. The third step consisted of ventilation/perfusion lung scintigraphy and right heart catheterisation. A transthoracic echocardiography was performed in patients without positive response in the screening questionnaire after 2years. CTEPH diagnosis required haemodynamic confirmation by right heart catheterisation and mismatched perfusion defects on lung scintigraphy. RESULTS: A total of 1191 patients were enrolled in 18 Spanish hospitals. Cumulative CTEPH incidence after 2-years PE was: 2.49% (95% CI: 1.68-3.56) and the incidence rate of CTEPH was 1.1 cases per 1000 person-months (95% CI: 0.725; 1.60). The CTEPH algorithm presented a lack of adherence of 29%; patient and physician preferences posed barriers to the triage algorithm The screening questionnaire, in patients who completed the follow-up, shows a specificity of 91.3% (89.0-93.2%) and negative predictive value of 99.4% (98.4-99.8%).. CONCLUSIONS: OSIRIS provides practiced clinical based data on the chronic thromboembolic pulmonary hypertension incidence and identified barriers to the implementation of a 3-step triage algorithm for its detection. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov identifier: NCT03134898.

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Keywords

• Chronic thromboembolic pulmonary hypertension; Diagnosis; Health decision making; Incidence; Pulmonary embolism; Pulmonary hypertension