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  3. Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group.

Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Oliver-Perez, M. Reyes
  • Arencibia-Sanchez, Octavio
  • Martin-Arriscado, Cristina
  • Muruzabal, Juan Carlos
  • Diaz-Feijoo, Berta
  • Cabrera, Silvia
  • Coronado, Pluvio
  • Martin-Salamanca, M. Belen
  • Pantoja-Garrido, Manuel
  • Marcos-Sanmartin, Josefa
  • Cabezas-Lopez, Elena
  • Lorenzo, Cristina
  • Beric, Duska
  • Rodriguez-Hernandez, Jose Ramon
  • Roldan-Rivas, Fernando
  • Gilabert-Estelles, Juan
  • Sanchez, Lourdes
  • Laseca-Modrego, Maria
  • Tauste-Rubio, Carmen
  • Gil-Ibanez, Blanca
  • Tejerizo-Garcia, Alvaro
  • On Behalf Of The Spain-Gog Group

Abstract

The main aim is to compare oncological outcomes and patterns of recurrence of patients with early-stage endometrioid endometrial cancer according to lymphovascular space invasion (LVSI) status. The secondary objective is to determine preoperative predictors of LVSI. We performed a multicenter retrospective cohort study. A total of 3546 women diagnosed with postoperative early-stage (FIGO I-II, 2009) endometrioid endometrial cancer were included. Co-primary endpoints were disease-free survival (DFS), overall survival (OS), and pattern of recurrence. Cox proportional hazard models were used for time-to-event analysis. Univariate and multivariate logistical regression models were employed. Positive LVSI was identified in 528 patients (14.6%) and was an independent prognostic factor for DFS (HR 1.8), OS (HR 2.1) and distant recurrences (HR 2.37). Distant recurrences were more frequent in patients with positive LVSI (78.2% vs. 61.3%, p < 0.01). Deep myometrial invasion (OR 3.04), high-grade tumors (OR 2.54), cervical stroma invasion (OR 2.01), and tumor diameter = 2 cm (OR 2.03) were independent predictors of LVSI. In conclusion, in these patients, LVSI is an independent risk factor for shorter DFS and OS, and distant recurrence, but not for local recurrence. Deep myometrial invasion, cervical stroma invasion, high-grade tumors, and a tumor diameter = 2 cm are independent predictors of LVSI.

Datos de la publicación

ISSN/ISSNe:
2072-6694, 2072-6694

Cancers  MDPI

Tipo:
Article
Páginas:
-
PubMed:
37174081
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
1,349 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 32

Citas Recibidas en Scopus: 20

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Keywords

  • LVSI; endometrial cancer; lymphovascular space invasion; recurrence; survival

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