Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group.

Data de publicació: 04/05/2023 Data Ahead of Print: 04/05/2023

Autors de IIS La Fe

Pablo Padilla Iserte

Autor

Autors aliens a IIS La Fe

Oliver-Perez, M. Reyes
Arencibia-Sanchez, Octavio
Martin-Arriscado, Cristina
Muruzabal, Juan Carlos
Diaz-Feijoo, Berta
Cabrera, Silvia
Coronado, Pluvio
Martin-Salamanca, M. Belen
Pantoja-Garrido, Manuel
Marcos-Sanmartin, Josefa
Cabezas-Lopez, Elena
Lorenzo, Cristina
Beric, Duska
Rodriguez-Hernandez, Jose Ramon
Roldan-Rivas, Fernando
Gilabert-Estelles, Juan
Sanchez, Lourdes
Laseca-Modrego, Maria
Tauste-Rubio, Carmen
Gil-Ibanez, Blanca
Tejerizo-Garcia, Alvaro
On Behalf Of The Spain-Gog Group

Abstract

The main aim is to compare oncological outcomes and patterns of recurrence of patients with early-stage endometrioid endometrial cancer according to lymphovascular space invasion (LVSI) status. The secondary objective is to determine preoperative predictors of LVSI. We performed a multicenter retrospective cohort study. A total of 3546 women diagnosed with postoperative early-stage (FIGO I-II, 2009) endometrioid endometrial cancer were included. Co-primary endpoints were disease-free survival (DFS), overall survival (OS), and pattern of recurrence. Cox proportional hazard models were used for time-to-event analysis. Univariate and multivariate logistical regression models were employed. Positive LVSI was identified in 528 patients (14.6%) and was an independent prognostic factor for DFS (HR 1.8), OS (HR 2.1) and distant recurrences (HR 2.37). Distant recurrences were more frequent in patients with positive LVSI (78.2% vs. 61.3%, p < 0.01). Deep myometrial invasion (OR 3.04), high-grade tumors (OR 2.54), cervical stroma invasion (OR 2.01), and tumor diameter = 2 cm (OR 2.03) were independent predictors of LVSI. In conclusion, in these patients, LVSI is an independent risk factor for shorter DFS and OS, and distant recurrence, but not for local recurrence. Deep myometrial invasion, cervical stroma invasion, high-grade tumors, and a tumor diameter = 2 cm are independent predictors of LVSI.

Dades de la publicació

ISSN/ISSNe:: 2072-6694, 2072-6694
Tipus:: Article
Pàgines:: -
DOI:: 10.3390/cancers15092612
PubMed:: 37174081
Factor d'Impacte:: 1,349 SCImago ℠
Quartil:: Q1 SCImago ℠

Documents

No hi ha documents

Mètriques

Filiacions

Oliver-Perez, M. Reyes:: Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Hospital Universitario 12 de Octubre, 12 de Octubre Research Institute (i+12), 28041 Madrid, Spain
Padilla-Iserte, Pablo:: Department of Gynaecologic Oncology, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain
Arencibia-Sanchez, Octavio:: Department of Gynecologic Oncology, University Hospital Materno-Infantil de Canarias, 35016 Las Palmas de Gran Canaria, Spain
Martin-Arriscado, Cristina:: Scientific Support Unit, Hospital Universitario 12 de Octubre, 12 de Octubre Research Institute (i+12), 28041 Madrid, Spain
Muruzabal, Juan Carlos:: Department of Gynecologic Oncology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain
Diaz-Feijoo, Berta:: Institute Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clinic de Barcelona, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Universitat de Barcelona, 08036 Barcelona, Spain
Cabrera, Silvia:: Gynecologic Oncology Unit, Gynecology Department, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
Coronado, Pluvio:: Women's Health Institute of the Hospital Clínico San Carlos, IdISSC, School of Medicine, Complutense University Madrid, 28040 Madrid, Spain
Martin-Salamanca, M. Belen:: Department of Gynecology, Hospital Universitario de Getafe, 28905 Madrid, Spain
Pantoja-Garrido, Manuel:: Department of Gynecology and Obstetrics, University Hospital Virgen Macarena, 41009 Sevilla, Spain
Marcos-Sanmartin, Josefa:: Departments of Obstetrics and Gynecology, Dr. Balmis General University Hospital, 03010 Alicante, Spain

Department of Public Health, Miguel Hernandez University, Sant Joan D'Alacant, 03550 Alicante, Spain

Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain
Cabezas-Lopez, Elena:: Department of Gynecologic Oncology, University Hospital Ramón y Cajal, 28034 Madrid, Spain
Lorenzo, Cristina:: Department of Obstetrics and Gynecology, Hospital Nuestra Señora de la Calendaria, 38010 Santa Cruz de Tenerife, Spain
Beric, Duska:: Department of Obstetrics and Gynecology, Hospital Universitario de Torrevieja, 03186 Alicante, Spain
Rodriguez-Hernandez, Jose Ramon:: Department of Gynecology and Obstetrics, University Hospital Virgen de La Arrixaca, El Palmar, 30120 Murcia, Spain
Roldan-Rivas, Fernando:: Department of Obstetrics and Gynaecology, Clinico Lozano Blesa Hospital, 50009 Zaragoza, Spain
Gilabert-Estelles, Juan:: Department of Pediatrics, Obstetrics and Gynecology, University General Hospital of Valencia, 46014 Valencia, Spain
Sanchez, Lourdes:: Department of Gynecology and Obstetrics, University General Hospital of Ciudad Real, 13005 Ciudad Real, Spain
Laseca-Modrego, Maria:: Department of Gynecologic Oncology, University Hospital Materno-Infantil de Canarias, 35016 Las Palmas de Gran Canaria, Spain
Tauste-Rubio, Carmen:: Department of Gynecologic Oncology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain
Gil-Ibanez, Blanca:: Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Hospital Universitario 12 de Octubre, 12 de Octubre Research Institute (i+12), 28041 Madrid, Spain
Tejerizo-Garcia, Alvaro:: Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Hospital Universitario 12 de Octubre, 12 de Octubre Research Institute (i+12), 28041 Madrid, Spain