How to select healthy sperm for intracytoplasmic sperm injection in samples with high sperm DNA fragmentation?

Fecha de publicación: 16/05/2023 Fecha Ahead of Print: 16/05/2023

Autores de IIS La Fe

Nicolás Garrido Puchalt

Autor

Participantes ajenos a IIS La Fe

Gul, Murat
Jindal, Sunil
Vogiatzi, Paraskevi
Saleh, Ramadan
Durairajanayagam, Damayanthi
Parmegiani, Lodovico
Boitrelle, Florence
Colpi, Giovanni M
Agarwal, Ashok

Grupos

Biología Reproductiva y Bioingeniería en Reproducción Humana

Leader

Nicolás Garrido Puchalt

Abstract

The body of evidence supports the negative impact of increased sperm DNA fragmentation (SDF) on natural fertility as well as assisted reproduction conditions. High SDF has been correlated with low pregnancy and delivery rates following intrauterine insemination. Also, high SDF is accused of reducing the rates of fertilization, implantation, pregnancy, and live birth following in-vitro fertilization (IVF). Despite no impact of high SDF on fertilization or pregnancy rates following intracytoplasmic sperm injection (ICSI), it has been correlated with poor embryo quality and a higher risk of miscarriage. Several methods have been introduced to help select sperm with the best DNA quality to be used in assisted reproductive technology procedures. These include magnetic-activated cell sorting, intracytoplasmic morphologically selected sperm injection, physiologic ICSI, and microfluidic sperm sorters, among others. This article aimed to discuss the impact of high SDF in infertile men on the reproductive outcome of couples undergoing IVF/ICSI. Additionally, this review highlights the principles, advantages, and limitations of different techniques that are currently used for the selection of sperm with intact DNA to be utilized for ICSI.

Datos de la publicación

ISSN/ISSNe:: 0031-0808, 1827-1898
Tipo:: Article
Páginas:: 148-158
DOI:: 10.23736/S0031-0808.23.04870-X
PubMed:: 37194246
Factor de Impacto:: 0,446 SCImago ℠
Cuartil:: Q3 SCImago ℠

Documentos

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Métricas

Filiaciones

Garrido, Nicolas:: Global Andrology Forum, Moreland Hills, OH, USA

Instituto de Investigación. IVI Foundation, Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain
Gul, Murat:: Global Andrology Forum, Moreland Hills, OH, USA
Jindal, Sunil:: Global Andrology Forum, Moreland Hills, OH, USA

Department of Andrology and Reproductive Medicine, Jindal Hospital and Fertility Center, Meerut, India
Vogiatzi, Paraskevi:: Global Andrology Forum, Moreland Hills, OH, USA

Andromed Health and Reproduction, Fertility and Reproductive Health Diagnostic Center, Athens, Greece
Saleh, Ramadan:: Global Andrology Forum, Moreland Hills, OH, USA

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt
Durairajanayagam, Damayanthi:: Global Andrology Forum, Moreland Hills, OH, USA

Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia
Parmegiani, Lodovico:: Andrology and IVF Center NextFertility Procrea, Lugano, Switzerland
Boitrelle, Florence:: Global Andrology Forum, Moreland Hills, OH, USA

Reproductive Biology, Fertility Preservation, Andrology, CECOS, Poissy Hospital, Poissy, France

Paris Saclay University, UVSQ, INRAE, BREED, Jouy-en-Josas, France
Colpi, Giovanni M:: Global Andrology Forum, Moreland Hills, OH, USA

Next Fertility Procrea, Lugano, Switzerland
Agarwal, Ashok:: American Center for Reproductive Medicine, Cleveland, OH, USA