Extravasation of monoclonal antibodies commonly used in oncology: Classification, management and the role of the pharmacist.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Bauters T
  • Clottens N

Abstract

INTRODUCTION: Extravasation by conventional cytotoxics has been well documented. While monoclonal antibodies are not considered to have the necrotic potential of some cytotoxic medicines, they require appropriate management in case of extravasation. However, fewer data are available on their classification and appropriate management when extravasation occurs. As monoclonal antibodies are being more commonly used in current daily oncology practice, this is an issue that cannot be ignored. METHODS: A scientific literature review on PubMed was conducted. All findings were critically appraised independently by 6 clinical pharmacists in order to provide a classification according to the extravasation hazard. RESULTS: A classification of non-conjugated and conjugated monoclonal antibodies according to extravasation hazard has been elaborated for different molecules frequently used in oncology. In addition, general management, in case extravasation of monoclonal antibodies occurs, has been proposed and the role of the pharmacist in the extravasation process has been described. CONCLUSION: A classification of hazard extent of extravasation of monoclonal antibodies with concurrent management based on literature data and expert consensus has been elaborated. In addition, the role of the oncology pharmacist is crucial in terms of follow-up and documentation of the extravasated monoclonal antibody and management is described.

Datos de la publicación

ISSN/ISSNe:
1078-1552, 1477-092X

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners  SAGE Publications

Tipo:
Article
Páginas:
488-492
PubMed:
37226295
Factor de Impacto:
0,374 SCImago
Cuartil:
Q3 SCImago

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Keywords

  • Extravasation; monoclonal antibodies; role of pharmacist

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