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Serum lipid biomarkers and inflammatory cytokines associated with onset and clinical status of patients with early knee osteoarthritis.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Cuenca-Martinez, Ferran
  • Calatayud, Joaquin
  • Casana, Jose
  • Ferrer-Sargues FJ
  • Blanco-Diaz, Maria

Grupos

Abstract

Introduction: Osteoarthritis (OA) is a common joint condition and one of the greatest causes of disability worldwide. The role of serum lipid and inflammatory biomarkers in the origin and development of the disease is not clear, although it could have important implications for diagnosis and treatment. The primary aim of this study was to evaluate differences of serum lipid and inflammatory biomarkers with knee EOA in comparison with matched controls, in order to determine the role of these factors in the origin of EOA. Methods: For this proposal, a cross-sectional study with a non-randomized sample was performed. 48 subjects with early osteoarthritis (EOA) and 48 matched controls were selected and serum lipid levels (total cholesterol, LDL, HDL) and inflammatory biomarkers C-reactive protein (CRP), uric acid (UA) were analyzed. In addition, clinical (pain, disability) and functional (gait speed, sit-to-stand) variables were measured to establish their relationship to serum lipid levels and inflammatory biomarkers. Results: Patients with EOA showed higher levels of total cholesterol LDL, UA, and CRP. Higher levels of total cholesterol, LDL and CRP were correlated with higher levels of pain intensity and higher disability (p < 0.05). In addition, UA and CRP were inversely correlated with gait speed and sit-to-stand tests (r = -0.038 to -0.5, p < 0.05). Conclusion: These results highlight the relevance of metabolic and proinflammatory aspects in the early stages of knee OA and could be key to developing early diagnoses to prevent the onset and development of the disease.

Copyright © 2023 Herrero-Manley, Alabajos-Cea, Suso-Martí, Cuenca-Martínez, Calatayud, Casaña, Viosca-Herrero, Vázquez-Arce, Ferrer-Sargues and Blanco-Díaz.

Datos de la publicación

ISSN/ISSNe:
2296-861X, 2296-861X

Frontiers in Nutrition  FRONTIERS MEDIA SA

Tipo:
Article
Páginas:
1126796-1126796
Factor de Impacto:
1,024 SCImago ℠
Cuartil:
Q1 SCImago ℠

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Keywords

  • cytokine, early osteoarthritis, inflammatory biomarkers, osteoarthritis, serum lipid

Proyectos asociados

RED DE ENFERMEDADES VASCULARES CEREBRALES. INVICTUS PLUS.

Investigador Principal: JUAN BAUTISTA SALOM SANVALERO

RD16/0019/0008 . INSTITUTO DE SALUD CARLOS III . 2017

OACTIVE. ADVANCED PERSONALISED, MULTI-SCALE COMPUTER MODELS PREVENTING OSTEOARTHRITIS. MODELOS COMPUTACIONALES MULTIESCALA, PERSONALIZADOS Y AVANZADOS PARA LA PREVENCIÓN DE LA ARTROSIS.

Investigador Principal: ENRIQUE VIOSCA HERRERO

777159_VIOSCA_SC1 . COMISION EUROPEA . 2017

EFECTO DE LA ADMINISTRACIÓN DE ALOPURINOL SOBRE LA PREVENCIÓN DE LA PÉRDIDA DE MASA MUSCULAR EN SUJETOS INMOVILIZADOS.

Investigador Principal: ENRIQUE VIOSCA HERRERO

ALMU_2011

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