Radiation therapy for vulvar cancer: consensus technical guidelines of the GINECOR working group of the Spanish Society of Radiation Oncology. Part 2: radiotherapy recommendations.

Fecha de publicación: 24/03/2023 Fecha Ahead of Print: 24/03/2023

Autores de IIS La Fe

Francisco Javier Celada Álvarez

Autor

Participantes ajenos a IIS La Fe

Cordoba Largo, Sofia
Rodriguez, Isabel Rodriguez
Rodriguez Villalba S
Najjari Jamal D
Anchuelo Latorre J
Garcia Cabezas S
de la Fuente Alonso C
Couselo Paniagua L
Martinez Montesinos I
Villafranca Iturre E
Belinchon Olmeda B
Farga Albiol D
Navarrete Solano PA
Sanchez Belda M
GINECOR (Spanish gynaecological tumors group of SEOR)

Grupos

Investigación Clínica y Traslacional en Cáncer

Leader

José Gómez Codina

Abstract

PURPOSE: The present consensus statement was developed by the GINECOR working group on behalf of the Spanish Society of Radiation Oncology (SEOR). This document provides an up-to-date review of the technical aspects in radiation treatment of vulvar cancer. METHODS: A two-round modified Delphi study was conducted to reach consensus on the appropriateness of technical aspects of external beam radiotherapy and brachytherapy. Three clinical scenarios were proposed: adjuvant treatment of vulvar cancer, radiation treatment of locally advanced vulvar carcinoma and locoregional recurrences. After the first round, an extensive analysis of current medical literature from peer-reviewed journal was performed to define evidence-based treatment options. In the second round, participants were asked to indicate their level of agreement with the preliminary recommendations according to the GRADE (Grade of Recommendation, Assessment, Development, and Evaluation) criteria, as follows: strongly agree; agree; neither agree nor disagree; disagree and strongly disagree. RESULTS: The main recommendations on external beam radiotherapy and brachytherapy, both in adjuvant setting and local advanced disease are summarized. Recommendations include treatment technique, treatment volume, and doses in target and organs at-risk. Taking into consideration the different clinical scenarios of recurrent disease, the radiation treatment should be individualized. CONCLUSIONS: In the absence of robust clinical data, these recommendations may help to select the optimal radiotherapy approach for this relatively rare cancer.

Datos de la publicación

ISSN/ISSNe:: 1699-048X, 1699-3055
Tipo:: Article
Páginas:: 2169-2182
DOI:: 10.1007/s12094-023-03101-z
Factor de Impacto:: 0,764 SCImago ℠
Cuartil:: Q2 SCImago ℠

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Filiaciones

Cordoba Largo, Sofia:: Department of Radiation Oncology, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain.
Rodriguez, Isabel Rodriguez:: Department of Radiation Oncology, La Paz University Hospital, Madrid, Spain
Rodriguez Villalba S:: Department of Radiation Oncology, Clinica Benidorm Hospital, Benidorm, Alicante, Spain
Najjari Jamal D:: Department of Radiation Oncology, Catalan Institut of Oncology, University of Barcelona, Hospitalet de Llobregat, Barcelona, Spain
Anchuelo Latorre J:: Department of Radiation Oncology, Marqués de Valdecilla University Hospital, Santander, Spain
Celada Alvarez F:: Department of Radiation Oncology, La Fe, University Hospital and Politécnico, Valencia, Spain
Garcia Cabezas S:: Department of Radiation Oncology, Reina Sofía, University Hospital, Córdoba, Spain
de la Fuente Alonso C:: Department of Radiation Oncology, Puerta de Hierro University Hospital, Majadahonda, Madrid, Spain
Couselo Paniagua L:: Department of Radiation Oncology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain
Martinez Montesinos I:: Department of Radiation Oncology, Complejo Hospitalario de Navarra, Pamplona, Spain
Villafranca Iturre E:: Department of Radiation Oncology, Complejo Hospitalario de Navarra, Pamplona, Spain
Belinchon Olmeda B:: Department of Radiation Oncology, La Paz University Hospital, Madrid, Spain
Farga Albiol D:: Department of Radiation Oncology, Consorcio Hospital General de Valencia, Valencia, Spain
Navarrete Solano PA:: Department of Radiation Oncology, Marqués de Valdecilla University Hospital, Santander, Spain
Sanchez Belda M:: Department of Radiation Oncology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain