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  3. Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry.

Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • De Luca, Giuseppe
  • Algowhary, Magdy
  • Uguz, Berat
  • Oliveira, Dinaldo C.
  • Ganyukov, Vladimir
  • Busljetik, Oliver
  • Cercek, Miha
  • Jensen, Lisette Okkels
  • Loh, Poay Huan
  • Calmac, Lucian
  • Ferrer, Gerard Roura i
  • Quadros, Alexandre
  • Milewski, Marek
  • Scotto D'Uccio, Fortunato
  • von Birgelen, Clemens
  • Versaci, Francesco
  • Ten Berg, Jurrien
  • Casella, Gianni
  • Wong Sung Lung, Aaron
  • Kala, Petr
  • Carrillo, Xavier
  • Dirksen, Maurits
  • Becerra Munoz, Victor
  • Lee, Michael Kang-yin
  • Juzar, Dafsah Arifa
  • de Moura Joaquim, Rodrigo
  • Paladino, Roberto
  • Milicic, Davor
  • Davlouros, Periklis
  • Bakraceski, Nikola
  • Zilio, Filippo
  • Donazzan, Luca
  • Kraaijeveld, Adriaan
  • Galasso, Gennaro
  • Arpad, Lux
  • Marinucci, Lucia
  • Guiducci, Vincenzo
  • Menichelli, Maurizio
  • Scoccia, Alessandra
  • Yamac, Aylin Hatice
  • Ugur Mert, Kadir
  • Flores Rios, Xacobe
  • Kovarnik, Tomas
  • Kidawa, Michal
  • Moreu, Jose
  • Flavien, Vincent
  • Fabris, Enrico
  • Martinez-Luengas, Inigo Lozano
  • Boccalatte, Marco
  • Bosa Ojeda, Francisco
  • Arellano-Serrano, Carlos
  • Caiazzo, Gianluca
  • Cirrincione, Giuseppe
  • Kao, Hsien-Li
  • Sanchis Fores, Juan
  • Vignali, Luigi
  • Pereira, Helder
  • Manzo-Silberman, Stephane
  • Ordonez, Santiago
  • Arat Ozkan, Alev
  • Scheller, Bruno
  • Lehitola, Heidi
  • Teles, Rui
  • Mantis, Christos
  • Antti, Ylitalo
  • Brum Silveira, Joao Antonio
  • Zoni, Cesar Rodrigo
  • Bessonov, Ivan
  • Uccello, Giuseppe
  • Kochiadakis, George
  • Alexopulos, Dimitrios
  • Uribe, Carlos E.
  • Kanakakis, John
  • Faurie, Benjamin
  • Gabrielli, Gabriele
  • Gutierrez Barrios, Alejandro
  • Bachini, Juan Pablo
  • Rocha, Alex
  • Tam, Frankie C. C.
  • Rodriguez, Alfredo
  • Lukito, Antonia Anna
  • Saint-Joy, Veauthyelau
  • Pessah, Gustavo
  • Tuccillo, Andrea
  • Ielasi, Alfonso
  • Cortese, Giuliana
  • Parodi, Guido
  • Burgadha, Mohammed Abed
  • Kedhi, Elvin
  • Lamelas, Pablo
  • Suryapranata, Harry
  • Nardin, Matteo
  • Verdoia, Monica

Grupos

Abstract

BACKGROUND: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. METHODS: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March-June 2019 and 2020. Patients were divided according to age (< or =75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. RESULTS: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825-0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24-1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05-1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. CONCLUSIONS: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic.

Datos de la publicación

ISSN/ISSNe:
2077-0383, 2077-0383

Journal of Clinical Medicine  MDPI

Tipo:
Article
Páginas:
-
PubMed:
36983119
Enlace a otro recurso:
www.scopus.com
Factor de Impacto:
1,040 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 5

Citas Recibidas en Scopus: 4

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Keywords

  • COVID-19; ST-segment elevation myocardial infarction; ageing

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