Portal de investigación
Changes in Liver Lipidomic Profile in G2019S-LRRK2 Mouse Model of Parkinson's Disease.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Corral Nieto Y
- Yakhine-Diop, Sokhna M. S.
- Moreno-Cruz, Paula
- Manrique García L
- Gabrielly Pereira A
- Morales-Garcia, Jose A.
- Niso-Santano, Mireia
- Gonzalez-Polo, Rosa A.
- Uribe-Carretero, Elisabet
- Durand, Sylvere
- Maiuri, Maria Chiara
- Paredes-Barquero, Marta
- Alegre-Cortes, Eva
- Canales-Cortes, Saray
- López de Munain A
- Perez-Castillo, Ana
- Kroemer, Guido
- Fuentes, Jose M.
- Bravo-San Pedro, Jose M.
Abstract
The identification of Parkinson's disease (PD) biomarkers has become a main goal for the diagnosis of this neurodegenerative disorder. PD has not only been intrinsically related to neurological problems, but also to a series of alterations in peripheral metabolism. The purpose of this study was to identify metabolic changes in the liver in mouse models of PD with the scope of finding new peripheral biomarkers for PD diagnosis. To achieve this goal, we used mass spectrometry technology to determine the complete metabolomic profile of liver and striatal tissue samples from WT mice, 6-hydroxydopamine-treated mice (idiopathic model) and mice affected by the G2019S-LRRK2 mutation in LRRK2/PARK8 gene (genetic model). This analysis revealed that the metabolism of carbohydrates, nucleotides and nucleosides was similarly altered in the liver from the two PD mouse models. However, long-chain fatty acids, phosphatidylcholine and other related lipid metabolites were only altered in hepatocytes from G2019S-LRRK2 mice. In summary, these results reveal specific differences, mainly in lipid metabolism, between idiopathic and genetic PD models in peripheral tissues and open up new possibilities to better understand the etiology of this neurological disorder.
Datos de la publicación
- ISSN/ISSNe:
- 2073-4409, 2073-4409
- Tipo:
- Article
- Páginas:
- -
- Factor de Impacto:
- 1,452 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Cells MDPI
Documentos
- No hay documentos
Filiaciones
Keywords
- lipids; liver; LRRK2; metabolome; neurodegeneration; Parkinson
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Cita
Corral Y,Yakhine SMS,Moreno P,Manrique L,Gabrielly A,Morales JA,Niso M,Gonzalez RA,Uribe E,Durand S,Maiuri MC,Paredes M,Alegre E,Canales S,López de Munain A,Perez J,Perez A,Kroemer G,Fuentes JM,Bravo JM. Changes in Liver Lipidomic Profile in G2019S-LRRK2 Mouse Model of Parkinson's Disease. Cells. 2023. 12. (5):806. IF:5,100. (2).