Molecular and Clinical Predictors of Quality of Life in Chronic Rhinosinusitis with Nasal Polyps.

Fecha de publicación: 09/02/2023 Fecha Ahead of Print: 09/02/2023

Autores de IIS La Fe

Julio Cortijo Gimeno

Autor
Miguel Armengot Carceller

Autor

Participantes ajenos a IIS La Fe

Brunet, Aina
Milara, Javier
Frias, Soledad

Grupos

Biomedicina Molecular, Celular y Genómica

Leader

José María Millán Salvador

Abstract

(1) Background: Factors influencing the quality of life (QoL) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) are poorly understood. We set out to determine the predictive factors on patients' QoL using the Sino-Nasal Outcome Test-22 (SNOT-22); (2) Methods: An ambispective analysis of data from patients diagnosed with CRSwNP in our institution. All the patients underwent a nasal polyp biopsy and completed the SNOT-22 questionnaire. Demographic and molecular data as well as the SNOT-22 scores were collected. Patients were classified in six subgroups considering the presence of asthma, non-steroidal drugs (NSAID) intolerance and corticosteroid resistance; (3) Results: The mean SNOT-22 score was 39. Considering the clinical parameters, the SNOT-22 value was significantly associated with NSAID intolerance (p = 0.04) and the endoscopic polyp score (p = 0.04). A high SNOT-22 value was also correlated with high tissue eosinophilia (p = 0.01) and high IL-8 expression; (4) Conclusions: Eosinophilia, IL-8 expression and NSAID intolerance can be used as predictors of worse QoL in patients with CRSwNP.

Datos de la publicación

ISSN/ISSNe:: 2077-0383, 2077-0383
Tipo:: Article
Páginas:: -
DOI:: 10.3390/jcm12041391
PubMed:: 36835929
Factor de Impacto:: 1,040 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Filiaciones

Brunet, Aina:: Department of Otorhinolaryngology and Head and Neck Surgery, Hospital Universitari Bellvitge, 08907 Barcelona, Spain

Institut d'Investigació Biomèdica (IDIBELL), 08908 Barcelona, Spain
Milara, Javier:: Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain

Pharmacy Unit, University General Hospital Consortium of Valencia, 46014 Valencia, Spain

Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain
Frias, Soledad:: Department of Otorhinolaryngology, Hospital de Manises, 46940 Valencia, Spain
Cortijo, Julio:: Department of Pharmacology, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain

Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain

Research and Teaching Unit, University General Hospital Consortium, 46014 Valencia, Spain
Armengot, Miguel:: Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Health Institute Carlos III, 28029 Madrid, Spain

Department of Otorhinolaryngology, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain

Molecular, Cellular and Genomic Biomedicine Group, Instituto de Investigación Sanitaria La Fe, 46020 Valencia, Spain

Surgery Department, Faculty of Medicine, University of Valencia, 46010 Valencia, Spain