Portal de investigación
Diarylureas: New Promising Small Molecules against Streptococcus mutans for the Treatment of Dental Caries.
Fecha de publicación:
Fecha Ahead of Print:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Iacopetta, Domenico
- Ceramella, Jessica
- Catalano, Alessia
- D'Amato, Assunta
- Lauria, Graziantonio
- Saturnino, Carmela
- Longo, Pasquale
- Sinicropi, Maria Stefania
Grupos
Abstract
Dental caries is a biofilm-mediated disease that represents a worldwide oral health issue. Streptococcus mutans has been ascertained as the main cariogenic pathogen responsible for human dental caries, with a high ability to form biofilms, regulated by the quorum sensing. Diarylureas represent a class of organic compounds that show numerous biological activities, including the antimicrobial one. Two small molecules belonging to this class, specifically to diphenylureas, BPU (1,3-bis[3,5-bis(trifluoromethyl)phenyl]urea) and DMTU (1,3-di-m-tolyl-urea), showed interesting results in studies regarding the antimicrobial activity against the cariogenic bacterium S. mutans. Since there are not many antimicrobials used for the prevention and treatment of caries, further studies on these two interesting compounds and other diarylureas against S. mutans may be useful to design new effective agents for the treatment of caries with generally low cytotoxicity.
Datos de la publicación
- ISSN/ISSNe:
- 2079-6382, 2079-6382
- Tipo:
- Article
- Páginas:
- -
- Factor de Impacto:
- 0,785 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
ANTIBIOTICS-BASEL Multidisciplinary Digital Publishing Institute (MDPI)
Citas Recibidas en Web of Science: 1
Documentos
- No hay documentos
Filiaciones
Keywords
- Streptococcus mutans; Streptococcus sobrinus; antimicrobials; biofilms; bis-aryl ureas; dental caries; diarylureas; diphenylureas; quorum sensing
Proyectos asociados
ESTRATEGIA INTEGRADA DE FOTODIAGNOSTICO COMBINANDO EVALUACION CLINICA, ENSAYOS BIOLOGICOS Y ESTUDIOS MECANISTICOS.
Investigador Principal: INMACULADA ANDREU ROS
PI16/01877 . INSTITUTO DE SALUD CARLOS III . 2017
Fotoalergia y fotocarcinogénesis debida a metabolitos y a fotoproductos de xenobióticos diana.
Investigador Principal: INMACULADA ANDREU ROS
ACIF/2018/153 . 2018
TEX4IRAS. Tejidos fotodinámicamente activos para prevenir las infecciones relacionadas con la asistencia sanitaria
Investigador Principal: INMACULADA ANDREU ROS
INNEST/2021/28 . AGENCIA VALENCIANA DE LA INNOVACION (AVI) . 2021
Validación y transferencia tecnológica de tejidos fotoactivos para reducir las enfermedades nosocomiales.
Investigador Principal: INMACULADA ANDREU ROS
CIAPOT/2021/33 . CONSELLERIA DE INNOVACIÓN, UNIVERSIDADES, CIENCIA Y SOCIEDAD DIGITAL . 2022
Cita
Iacopetta D,Ceramella J,Catalano A,D'Amato A,Lauria G,Saturnino C,Andreu I,Longo P,Sinicropi MS. Diarylureas: New Promising Small Molecules against Streptococcus mutans for the Treatment of Dental Caries. Antibiotics (Basel). 2023. 12. (1):112. IF:4,300. (1).