Ethanol reduces zincosome formation in cultured astrocytes.

Autors de IIS La Fe

• Raúl Ballestín Hinojosa

  Autor

• María Del Pilar Marín Muela

  Autor

• Ana María Romero Pelechano

  Autor

• Jaime Renau Piqueras

  Autor

• Xavier Ponsoda Marti

  Autor

Autors aliens a IIS La Fe

• Molowny A
• Esteban-Pretel G
• Lopez-Garcia C

Abstract

Zinc is an ion that participates in basic cellular and tissular functions. Zinc deficiency is present in many physiological and health problems affecting most body organs, including the brain. Among the circumstances involved in zinc deficiency, ethanol consumption is probably one of the most frequent. A dietary zinc supplement has been proposed as possibly being an efficient method to palliate zinc deficiency. Astrocytes form part of the hematoencephalic barrier, and they are apparently implicated in the homeostasis of the neuronal medium. In this work, we analyze the effect of ethanol on extracellular zinc management by rat astrocytes in culture.