Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis.

Autores de IIS La Fe

• Sara Carratalà Boscà

  Autor

• Carlos Quintanilla Bordas

  Autor

• Sara María García Gil-Perotín

  Autor

• Laura Cubas Núñez

  Autor

• Jéssica Castillo Villalba

  Autor

• Francisco Carlos Pérez Miralles

  Autor

• Bonaventura Casanova Estruch

  Autor

Participantes ajenos a IIS La Fe

• Alcala Vicente, Carmen
• Lacruz, Laura
• Gascon, Francisco
• Sanz, Maria T.
• Carcelen-Gadea, Maria
• Mallada, Javier
• Carreres, Joan
• Gabaldon Torres, Laura
• Dominguez JA
• Canizares, Emmanuel
• Gasque Rubio, Raquel

Grupos

• Investigación en Neuroinmunología y Esclerosis Múltiple

Abstract

ObjectiveTo determine baseline cerebrospinal fluid and magnetic resonance imaging (MRI) variables at the onset of a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) that predict evolution to secondary progressive MS (SPMS). Methods276 CIS patients with a minimum follow-up of 10 years were studied. Baseline presence of oligoclonal IgG and IgM bands (OCGB and OCMB respectively); number of brain T2 lesions (B-T2L), brain gadolinium enhancement lesions (brain-GEL), cervical spinal cord T2 lesions (cSC-T2L); and fulfillment of 2017 McDonald criteria among other variables were collected. Results14 patients ended up with a non-MS condition. 138/276 CIS patients fulfilled 2017 McDonald criteria. Mean age was 32.4 years, 185 female. 227 received treatment, 95 as CIS. After a mean follow-up of 12 years, 36 patients developed SPMS. Conversion to SPMS was associated with OCGB (p = 0.02), OCMB (p = 0.0001); >= 9 B-T2L (p = 0.03), brain-GEL (p = 0.03), and cSC-T2L (p = 0.03). However, after adjusting for sex, age, BT2L, brain-GEL, SC-T2, and OCMB status, only OCMB (HR 4.4, 1.9-10.6) and cSC-T2L (HR 2.2, 1.0-6.2) suggested an independent association with risk of conversion to SPMS. Patients with both risk factors had a HR of 6.12 (2.8-12.9). DiscussionOCMB and SC-T2 lesions are potential independent predictors of conversion to SPMS.

Copyright © 2022 Alcalá Vicente, Lacruz, Gascón, Carratalà, Quintanilla-Bordás, Sanz, Carcelén-Gadea, Mallada, Carreres, Gabaldón Torres, Dominguez, Cañizares, Gil-Perotin, Cubas, Gasqué Rubio, Castillo-Villalba, Pérez-Miralles and Casanova.

Keywords

• OCMB; oligoclonal M bands; spinal cord; secondary progressive MS; multiple sclerosis