Depression and Suicide Risk in Mild Cognitive Impairment: The Role of Alzheimer's Disease Biomarkers

Fecha de publicación: 01/01/2022

Autores de IIS La Fe

• Rogelio Alberto Lopez Cuevas

  Autor

• 

  Miguel Baquero Toledo

  Autor

Participantes ajenos a IIS La Fe

• Ferrer-Cairols, Ines
• Montoliu, Teresa
• Crespo-Sanmiguel, Isabel
• Pulopulos, Matias M.
• Hidalgo, Vanesa
• Gomez, Enriqueta
• Cuevas, Ana
• Martin, Nuria
• Salvador, Alicia

Grupos

• Grupo de Investigación en Enfermedad de Alzheimer (GINEA)

  

  Investigador Principal

  Miguel Baquero Toledo

Abstract

Background: Patients with depression and mild cognitive impairment (MCI) are at greater risk of developing dementia. Depression involves a higher risk of suicidal ideation (SI) and suicide attempts (SA). Biomarkers of Alzheimer's Disease (AD) could help to clarify the role of depression and SI in AD. Method: Fifty-nine participants aged > 50 with criteria of MCI positive (MCI-AD) (n=22) and negative (MCI-Non AD) (n=24) AD and healthy controls (HC) (n=13) were evaluated. We used the Geriatric Depression Scale (GDS-30) and the GDS-SI factor to measure depression and indirect risk for suicide, respectively. Additionally, AD biomarkers such as amyloid-beta (A beta), hyperphosphorilated tau (P-tau), and total tau (T-tau) in cerebrospinal fluid (CSF) were analyzed. Results: No significant differences between the groups were found in depression. However, in the MCI-AD group, lower P-tau and T-tau levels were related to higher GDS-SI scores, suggesting that MCI-AD patients with lower AD pathology are at a higher risk of suicide. Conclusions: The result highlights the importance of considering SI in the initial phases of AD, and the potential role of AD biomarkers in early detection of symptoms.

Keywords

• Depression; Suicidal ideation; Suicide risk; Mild cognitive impairment; Amyloid-beta; Tau