Portal de investigación
Meta-analysis of the efficacy of ketamine in postoperative pain control in adolescent idiopathic scoliosis patients undergoing spinal fusion
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Mariscal, Gonzalo
- Morales, Jorge
- Perez, Silvia
- Antonio Rubio-Belmar, Pedro
- Bovea-Marco, Miquel
- Bas, Jose Luis
Abstract
PURPOSE: In this meta-analysis, we aim to compare ketamine use versus a control group (saline solution) during induction of anesthesia in adolescent idiopathic scoliosis patients undergoing fusion surgery in terms of postoperative opioid consumption, pain control, and side effects. METHODS: A PubMed search of studies published over the last 20 years using the descriptor/terms "ketamine AND scoliosis" was performed. Baseline characteristics of each article were obtained and efficacy measures analyzed (morphine equivalent treatment at 24, 48, and 72 h postoperatively, complications (vomiting/nausea and pruritus), length of hospital stay (days); and pain score (VAS)) (Review Manager 5.4 software package). RESULTS: Five randomized clinical trials were included. Morphine administration showed statistically significant differences at 24 and 48 h (MD - 0.15, 95% CI - 0.18 to - 0.12) and (MD - 0.26, 95% CI - 0.31 to - 0.21) between the ketamine and control (saline solution), respectively. No intergroup differences were found regarding nausea/vomiting and pruritus (OR 0.77, 95% CI 0.35 to 1.67) and (OR 0.71, 95% CI 0.31 to 1.62), respectively, same as for the pain score (MD - 0.75, 95% CI - 1.71 to 0.20). CONCLUSIONS: The use intraoperative and postoperative continuous low doses of ketamine significantly reduces opioid use throughout the first 48 h in patients with AIS who undergo posterior spinal fusion.
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Datos de la publicación
- ISSN/ISSNe:
- 0940-6719, 1432-0932
- Tipo:
- Article
- Páginas:
- 3492-3499
- PubMed:
- 36253657
- Factor de Impacto:
- 1,231 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
EUROPEAN SPINE JOURNAL SPRINGER
Citas Recibidas en Web of Science: 2
Documentos
- No hay documentos
Filiaciones
Keywords
- Adolescent idiopathic scoliosis; Ketamine; Meta-analysis; Pain control; Scoliosis; Spinal fusion
Cita
Mariscal G,Morales J,Perez S,Antonio Rubio P,Bovea M,Bas JL,BAS P,BAS T. Meta-analysis of the efficacy of ketamine in postoperative pain control in adolescent idiopathic scoliosis patients undergoing spinal fusion. Eur. Spine J. 2022. 31. (12):p. 3492-3499. IF:2,800. (2).