Cellular Indices and Outcome in Patients with Acute Venous Thromboembolism.

Fecha de publicación: 01/01/2022

Autores de IIS La Fe

Alberto García Ortega

Autor

Participantes ajenos a IIS La Fe

Siddiqui, Fakiha
Kantarcioglu, Bulent
Sinacore, James
Tafur, Alfonso
Demelo-Rodriguez, Pablo
Antonio Nieto, Jose
Usandizaga, Esther
Fareed, Jawed
Monreal, Manuel
The Riete Investigators

Abstract

Background Cellular indices provide integrative information about systemic inflammation status which is readily available from routine laboratory parameters. This study aimed to evaluate the prognostic role of three cellular indices in patients with venous thromboembolism (VTE). Methods The RIETE registry database was used to determine the association between the baseline neutrophil-to-lymphocyte-ratio (NLR), platelet-to-lymphocyte-ratio (PLR) and systemic-immune-inflammation-index (SII) for 90-day adverse outcomes in patients with acute VTE. Results From January 2020 to April 2021, 4487 patients with acute VTE were recruited in the RIETE registry. Of these, 2683 presented with symptomatic pulmonary embolism (PE); 283 with incidental PE; 1129 with lower-limb deep vein thrombosis (DVT); 175 with upper-limb DVT; 69 with splanchnic vein thrombosis; 142 with superficial vein thrombosis and 20 with retinal vein thrombosis. Mean values were: NLR 5.9 +/- 7.1, PLR 190 +/- 158 and SII 1459 +/- 2028. During the first 90-days, 38 patients (0.8%) developed recurrent DVT, 45 (1.0%) had recurrent PE, 152 (3.4%) suffered major bleeding, and 484 (11%) died. On multivariable analysis, patients with NLR >4.41 were at an increased risk for major bleeding and patients with NLR >4.96 were at the risk of death, while those with SII >1134.5 were at increased risk for death. Conclusions This study reports the results of a large cohort to date which evaluate the prognostic value of three cellular indices simultaneously in patients with acute VTE. Results support that none of the three baseline cellular indices were sufficient for prediction of VTE recurrences in acute VTE patients. The patients with higher baseline NLR values were at an increased risk of major bleeding or death, those with high SII values were only at an increased risk for mortality.

Datos de la publicación

ISSN/ISSNe:: 1076-0296, 1938-2723
Tipo:: Article
Páginas:: -
DOI:: 10.1177/10760296221113346
Factor de Impacto:: 0,758 SCImago ℠
Cuartil:: Q2 SCImago ℠

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Filiaciones

Siddiqui, Fakiha:: 1Department of Pathology & Laboratory Medicine, Cardiovascular Research Institute, 550858Health Science Division, 2456Loyola University Chicago, Maywood, Illinois, USA.

2Program in Health Sciences, 16728UCAM - Universidad Católica San Antonio de Murcia, Murcia, Spain.
Garcia-Ortega, Alberto:: 3Respiratory Department, 16273Hospital Universitari i Politècnic La Fe, Valencia, Spain.
Kantarcioglu, Bulent:: 1Department of Pathology & Laboratory Medicine, Cardiovascular Research Institute, 550858Health Science Division, 2456Loyola University Chicago, Maywood, Illinois, USA.
Sinacore, James:: 4Department of Public Health, 2456Loyola University Chicago, Maywood, Illinois, USA.
Tafur, Alfonso:: 5Department of Medicine and Vascular Medicine, 3271Evanston NorthShore University Health System. Evanston, Illinois, USA.
Demelo-Rodriguez, Pablo:: 6Department of Internal Medicine, 16483Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Antonio Nieto, Jose:: 7Department of Internal Medicine, 16297Hospital General Virgen de la Luz, Cuenca, Spain.
Usandizaga, Esther:: 8Department of Internal Medicine, 223474Hospital Sant Joan Despí-Moises Broggi, Barcelona, Spain.
Fareed, Jawed:: 1Department of Pathology & Laboratory Medicine, Cardiovascular Research Institute, 550858Health Science Division, 2456Loyola University Chicago, Maywood, Illinois, USA.
Monreal, Manuel:: 10Chair for the Study of Thromboembolic Disease, Faculty of Health Sciences, UCAM, 16728Universidad Católica San Antonio de Murcia, Murcia, Spain.

9Department of Internal Medicine, 16514Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.

Keywords

neutrophil to lymphocyte ratio (NLR); platelet to lymphocyte ratio (PLR); systemic immune inflammation index (SII); venous thromboembolism (VTE); major bleeding; mortality