The Human Mycobiome in Chronic Respiratory Diseases: Current Situation and Future Perspectives.

Fecha de publicación: 13/04/2022 Fecha Ahead of Print: 13/04/2022

Autores de IIS La Fe

Rafael Canton Moreno

Autor
Miguel Ángel Martínez García

Autor

Participantes ajenos a IIS La Fe

de Dios Caballero J
Ponce-Alonso M
García-Clemente MM
Gómez G de la Pedrosa E
López-Campos JL
Máiz L
Del Campo R

Grupos

Neumología

Leader

Miguel Ángel Martínez García

Abstract

Microbes play an important role in the pathogenesis of chronic lung diseases, such as chronic obstructive pulmonary disease, cystic fibrosis, non-cystic fibrosis bronchiectasis, and asthma. While the role of bacterial pathogens has been extensively studied, the contribution of fungal species to the pathogenesis of chronic lung diseases is much less understood. The recent introduction of next-generation sequencing techniques has revealed the existence of complex microbial lung communities in healthy individuals and patients with chronic respiratory disorders, with fungi being an important part of these communities' structure (mycobiome). There is growing evidence that the components of the lung mycobiome influence the clinical course of chronic respiratory diseases, not only by direct pathogenesis but also by interacting with bacterial species and with the host's physiology. In this article, we review the current knowledge on the role of fungi in chronic respiratory diseases, which was obtained by conventional culture and next-generation sequencing, highlighting the limitations of both techniques and exploring future research areas.

Datos de la publicación

ISSN/ISSNe:: 2076-2607, 2076-2607
Tipo:: Article
Páginas:: -
DOI:: 10.3390/microorganisms10040810
PubMed:: 35456861
Factor de Impacto:: 0,862 SCImago ℠
Cuartil:: Q2 SCImago ℠

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Métricas

Filiaciones

de Dios Caballero J:: Department of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute, 28034 Madrid, Spain

CIBER of Infectious Diseases (CIBERINFEC), Institute of Health Carlos III, 28029 Madrid, Spain
Cantón R:: Department of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute, 28034 Madrid, Spain

CIBER of Infectious Diseases (CIBERINFEC), Institute of Health Carlos III, 28029 Madrid, Spain
Ponce-Alonso M:: Department of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute, 28034 Madrid, Spain

CIBER of Infectious Diseases (CIBERINFEC), Institute of Health Carlos III, 28029 Madrid, Spain
García-Clemente MM:: Department of Pneumology, Central Asturias University Hospital, 33011 Oviedo, Spain

Principality Asturias Health Research Institute (ISPA), 33011 Oviedo, Spain
Gómez G de la Pedrosa E:: Department of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute, 28034 Madrid, Spain

CIBER of Infectious Diseases (CIBERINFEC), Institute of Health Carlos III, 28029 Madrid, Spain
López-Campos JL:: Medical-Surgical Unit for Respiratory Diseases (CIBERES), Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, University of Seville, 41013 Sevilla, Spain

CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain
Máiz L:: CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain

Department of Pneumology, Ramón y Cajal University Hospital, 28034 Madrid, Spain
Del Campo R:: Department of Microbiology, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute, 28034 Madrid, Spain

CIBER of Infectious Diseases (CIBERINFEC), Institute of Health Carlos III, 28029 Madrid, Spain
Martínez-García MÁ:: CIBER of Respiratory Diseases (CIBERES), Institute of Health Carlos III, 28029 Madrid, Spain

Department of Pneumology, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain