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Awareness of Diagnosis in Persons with Early-Stage Alzheimer's Disease: An Observational Study in Spain.

Fecha de publicación: Fecha Ahead of Print:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Villarejo-Galende, Alberto
  • Garcia-Arcelay, Elena
  • Piñol-Ripoll G
  • del Olmo-Rodriguez, Antonio
  • Viñuela F
  • Boada, Merce
  • Franco-Macias, Emilio
  • de la Peña AI
  • Riverol, Mario
  • Puig-Pijoan, Albert
  • Abizanda-Soler, Pedro
  • Arroyo, Rafael
  • Feria-Vilar, Inmaculada
  • Balasa, Mircea
  • Berbel, Angel
  • Rodriguez-Rodriguez, Eloy
  • Vieira-Campos, Alba
  • Garcia-Ribas, Guillermo
  • Rodrigo-Herrero, Silvia
  • Lleo, Albert
  • Maurino, Jorge

Grupos

Abstract

INTRODUCTION: Limited information is available on people's experiences of living with Alzheimer's disease (AD) at earlier stages. This study assessed awareness of diagnosis among people with early-stage AD and its impact on different person-centered outcome measures. METHODS: We conducted an observational, cross-sectional study in 21 memory clinics in Spain. Persons aged 50-90 years, diagnosed with prodromal or mild AD (NIA/AA criteria), a Mini Mental State Examination (MMSE) score = 22, and a Clinical Dementia Rating-Global score (CDR-GS) of 0.5 or 1.0 were recruited. The Representations and Adjustment to Dementia Index (RADIX) was used to assess participants' beliefs about their condition and its consequences. RESULTS: A total of 149 persons with early-stage AD were studied. Mean (SD) age was 72.3 (7.0) years and 50.3% were female. Mean duration of AD was 1.4 (1.8) years. Mean MMSE score was 24.6 (2.1) and 87.2% had a CDR-GS score of 0.5. Most participants (n = 84, 57.5%) used a descriptive term related to specific AD symptoms (e.g., memory difficulties) when asked what they called their condition. Participants aware of their diagnosis using the term AD (n = 66, 45.2%) were younger, had more depressive symptoms, and poorer life satisfaction and quality of life compared to those without awareness of their specific diagnosis. Practical and emotional consequences RADIX scores showed a significant negative correlation with Quality of Life in Alzheimer's Disease score (rho = - 0.389 and - 0.413, respectively; p < 0.0001). Years of education was the only predictor of awareness of AD diagnosis [OR = 1.04 (95% CI 1.00-1.08); p = 0.029]. CONCLUSIONS: Awareness of diagnosis was a common phenomenon in persons with early-stage AD negatively impacting their quality of life. Understanding illness representations in earlier stages may facilitate implementing optimized care that supports improved quality of life and well-being.

© 2022. The Author(s).

Datos de la publicación

ISSN/ISSNe:
2193-8253, 2193-6536

Neurology And Therapy  SPRINGER LONDON LTD

Tipo:
Article
Páginas:
1183-1192
PubMed:
35648383
Factor de Impacto:
1,003 SCImago ℠
Cuartil:
Q2 SCImago ℠

Citas Recibidas en Web of Science: 5

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Keywords

  • Alzheimer’s disease; Awareness; Diagnosis; Illness representation; Quality of life; Well-being

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