A real-life study of the medium to long-term effectiveness of a hypercaloric, hyperproteic enteral nutrition formula specifically for patients with diabetes on biochemical parameters of metabolic control and nutritional status.
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Ballesteros Pomar MD
- Lardiés Sánchez B
- Ramos Carrasco A
- Suárez Gutiérrez L
- Yoldi Arrieta A
- Sorribes Carreras P
- Gutiérrez Medina S
- Molina Soria JB
- Berrio Miranda M
- Leyva Martínez MS
- Torregrosa Suau O
- Oliván Usieto MT
- Villazón González F
- Abilés Osinaga J
- Martín Echevarría E
Grupos
Abstract
INTRODUCTION: Although current recommendations suggest the use of specific formulas in enteral nutrition in people with diabetes, there is little evidence of their long-term effectiveness in glycemic control. The main objective of this study is to evaluate the long-term efficacy (24 weeks) of a specific high-protein hypercaloric enteral nutrition formula for people with diabetes in glycemic control and in their improvement in nutritional status. METHODOLOGY: This was a multicenter, prospective, observational, real-life study of patients with long-term enteral nutrition prescription through gastrostomy or nasogastric tube who received a high protein hypercaloric formula specific for diabetes. Once the participant's informed consent was obtained and the inclusion and exclusion criteria were verified, data relating to glycemic control, inflammation parameters, biochemical data, nutritional status and gastrointestinal tolerance at 0, 12 and 24 weeks were collected. RESULTS: 112 patients were recruited, 44.6% women, age 75.0 (12.0) years and a mean time of evolution of diabetes of 18.1 (9.5) years. The percentage of patients with malnutrition according to VGS decreased throughout the treatment from 78.6% to 29.9% (p?<?0.001). Glycemic and HbA1c levels were significantly reduced at 12 and 24 weeks (Blood glucose 155.9-139.0-133.9?mg/dl, p?<?0.001; HbA1c 7.7-7.3-7.1%, p?<?0.001) while no significant changes were observed in cholesterol, triglycerides, creatinine, or glomerular filtration. A significant increase in variables related to nutritional status was observed: weight, the BMI, albumin, prealbumin and transferrin, and CRP levels were significantly reduced and the CRP/Albumin ratio decreased. Gastrointestinal tolerance was good, the number of patients with moderate-severe symptoms was small, and did not change throughout the follow-up. CONCLUSION: Our real-life study suggests that the use of a specific hyperprotein hypercaloric formula for diabetes during a 6-month nutritional treatment allows adequate glycemic control and nutritional evolution, with good gastrointestinal tolerance.
Copyright © 2022. Published by Elsevier España, S.L.U.
Datos de la publicación
- ISSN/ISSNe:
- 2530-0180, 2530-0180
- Tipo:
- Article
- Páginas:
- 331-337
- PubMed:
- 35523676
ENDOCRINOLOGIA DIABETES Y NUTRICION ELSEVIER SCIENCE BV
Documentos
- No hay documentos
Filiaciones
Keywords
- Desnutrición; Diabetes; Enteral nutrition; Fórmula enteral específica para diabetes; HbA1c; Malnutrition; Nutrición enteral; Specific enteral formula for diabetes
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Cita
Ballesteros MD,Lardiés B,ARGENTE M,Ramos A,Suárez L,Yoldi A,Sorribes P,Gutiérrez S,Molina JB,Berrio M,Leyva MS,Torregrosa O,Oliván MT,Villazón F,Abilés J,Martín E,GARCÍA K. A real-life study of the medium to long-term effectiveness of a hypercaloric, hyperproteic enteral nutrition formula specifically for patients with diabetes on biochemical parameters of metabolic control and nutritional status. Endocrinol Diabetes Nutr (Engl Ed). 2022. 69. (5):p. 331-337. IF:1,900. (4).